HDAC6-IN-6
HDAC6-IN-6 (compound 6a) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-6 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-6 can enhance neurite outgrowth without significant neurotoxicity.
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- CAS. Nr.: 2413603-10-6
- Formel: C20H15N3O2
- Molecular Weight:329.35
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
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HDAC6 0.025 ± 0. μM (IC50) |
HDAC1 0.34 ± 0.0 μM (IC50) |
HDAC 0.55 ± 0.0 μM (IC50) |
HDAC9 0.57 ± 0.0 μM (IC50) |
HDAC7 0.65 ± 0.0 μM (IC50) |
HDAC5 0.85 ± 0.0 μM (IC50) |
HDAC3 1.22 ± 0.0 μM (IC50) |
HDAC2 1.57 ± 0.0 μM (IC50) |
HDAC4 2.24 ± 0.0 μM (IC50) |
In Vitro
HDAC6-IN-6 (compound 6a) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 7.96 and 8 μM, respectively[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2413603-10-6
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Molecular Weight 329.35
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Formel C20H15N3O2
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SMILES
O=C(C1=CC=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=CC=C42)NO
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
HDAC6-IN-6 Related Classifications
HY-146679 Related Classifications
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