Herbacitrin
Herbacitrin is a HIV-1 reverse transcriptase and integrase inhibitor with IC50 values of 21.5 μM and 2.15 μM, respectively. Herbacitrin inhibits the growth of normal mouse embryonic cells, hybridoma HF cells, and ras/myc-transformed SFME cells, regulates the growth of ras-transformed SFME cells, and exhibits cytotoxic activity against hybridoma HF cells. Herbacitrin can be used in studies related to HIV-1 infection.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 35815-07-7
- Formel: C21H20O12
- Molecular Weight:464.38
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
|
HIV-1 |
Herbacitrin (4 days) exhibits dose-dependent cytotoxicity toward MT-4 and MT-2 human T-cell lines, with CC50 values of 27.8 μM and 63.64 μM, respectively[1].
Herbacitrin (2.1 μM; 5 days) significantly inhibits HIV-1 replication in HIV-1-infected MT-4 and MT-2 human T-cell lines, as measured by reduced p24 core protein levels[1].
Herbacitrin (2.15-21.5 μM) significantly inhibits recombinant HIV-1 reverse transcriptase activity at 21.5 μM, but not at 2.15 μM[1].
Herbacitrin (2.15-21.5 μM) significantly inhibits recombinant HIV-1 integrase activity at both 2.15 μM and 21.5 μM, with greater potency at the higher concentration[1].
Herbacitrin (10-50 μM; 6 days) dose-dependently inhibits the growth of normal Balb/c-derived SFME cells, shows biphasic stimulatory/inhibitory effects on ras-transformed Balb/c-derived SFME cells, and exerts only weak growth inhibition on ras/myc-transformed Balb/c-derived SFME cells, with complete inhibition of normal cells occurring at 40-50 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HIV-1-infected MT-4, MT-2 human T-cell lines
-
Concentration:2.1 μM
-
Incubation Time:5 days
-
Result:Reduced HIV-1 replication in both MT-4 and MT-2 cells, as shown by decreased p24 core protein levels, and exhibited statistically significant differences compared with the negative control.
-
Cell Line:normal serum-free mouse embryo (SFME) cells, ras-transformed SFME cells, ras/myc-transformed SFME cells (all derived from Balb/c mouse embryonic cells)
-
Concentration:10 μM, 20 μM, 30 μM, 40 μM, 50 μM
-
Incubation Time:6 days
-
Result:Markedly inhibited normal SFME cell growth dose-dependently, induced biphasic growth regulation in ras-transformed SFME cells, and weakly suppressed ras/myc-transformed SFME cell proliferation.
Chemical Information
-
CAS. Nr. 35815-07-7
-
Molecular Weight 464.38
-
Formel C21H20O12
-
SMILES
OC1=C2C(C(C(O)=C(C3=CC=C(C=C3)O)O2)=O)=C(C=C1O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)O
-
Structure Classification
-
Initial Source
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Herbacitrin Related Classifications
HY-N15438 Related Classifications
Powered by Bioz