Iperoxo
Based on 2 publication(s) in Google Scholar
Iperoxo is a potent superagonist of muscarinic acetylcholine receptor (mAChR) that activates M1, M2 and M3 receptors with pEC50 of 9.87, 10.1 and 9.78. Iperoxo can be used for direct probing activation-related conformational transitions of muscarinic receptors when labeled with tritium.
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- Reinheit: 99.48%
- CAS. Nr.: 247079-84-1
- Formel: C10H17IN2O2
- Molecular Weight:324.16
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Publications Citing Use of MedChemExpress (MCE) Iperoxo
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Biologische Aktivität
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mAChR2 10.1 (pEC50) |
mAChR1 9.87 (pEC50) |
mAChR3 9.78 (pEC50) |
Iperoxo (0.1 nM-10 μM) activates muscarinic receptor, causes downstream signaling pathway responses, leads to phosphoinositide generation, calcium ion mobilization, and ERK1/2 phosphorylation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 247079-84-1
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Appearance Solid
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Molecular Weight 324.16
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Formel C10H17IN2O2
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Color White to off-white
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SMILES
C[N+](C)(C)CC#CCOC1=NOCC1.[I-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Mol Sci
Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking. [Abstract]2023 Apr 16;24(8):7356. PMID: 37108518 -
J Neurochem
Beta-Arrestin2-Biased Activation by Pilocarpine Suppresses Microglial Inflammatory Response. [Abstract]2025 Dec;169(12):e70334. PMID: 41457680
Lösungsmittel & Löslichkeit
DMSO : 62.5 mg/mL (192.81 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Schrage R, et, al. Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor. Br J Pharmacol. 2013 May;169(2):357-70. [Content Brief]
[2]. Schrage R, et, al. New insight into active muscarinic receptors with the novel radioagonist [³H]iperoxo. Biochem Pharmacol. 2014 Aug 1;90(3):307-19. [Content Brief]
[3]. Kruse AC, et al., Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 2013 Dec 5;504(7478):101-6. [Content Brief]
[4]. Matera C, et al., Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity. Eur J Med Chem. 2014 Mar 21;75:222-32. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0849 mL | 15.4245 mL | 30.8490 mL | 77.1224 mL |
| 5 mM | 0.6170 mL | 3.0849 mL | 6.1698 mL | 15.4245 mL | |
| 10 mM | 0.3085 mL | 1.5424 mL | 3.0849 mL | 7.7122 mL | |
| 15 mM | 0.2057 mL | 1.0283 mL | 2.0566 mL | 5.1415 mL | |
| 20 mM | 0.1542 mL | 0.7712 mL | 1.5424 mL | 3.8561 mL | |
| 25 mM | 0.1234 mL | 0.6170 mL | 1.2340 mL | 3.0849 mL | |
| 30 mM | 0.1028 mL | 0.5141 mL | 1.0283 mL | 2.5707 mL | |
| 40 mM | 0.0771 mL | 0.3856 mL | 0.7712 mL | 1.9281 mL | |
| 50 mM | 0.0617 mL | 0.3085 mL | 0.6170 mL | 1.5424 mL | |
| 60 mM | 0.0514 mL | 0.2571 mL | 0.5141 mL | 1.2854 mL | |
| 80 mM | 0.0386 mL | 0.1928 mL | 0.3856 mL | 0.9640 mL | |
| 100 mM | 0.0308 mL | 0.1542 mL | 0.3085 mL | 0.7712 mL |
Iperoxo Related Classifications
HY-122743 Related Classifications
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