Art. -Nr.: HY-132822

Ivospemin

(Synonyms: SBP-101)

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Ivospemin (SBP-101) is an antineoplastic spermine analog. Ivospemin has shown efficacy in slowing pancreatic and ovarian tumor progression in vitro and in vivo. Ivospemin shows modest induction of polyamine catabolism, but stronger repression of ornithine decarboxylase activity. Ivospemin is promising for research of cancers.

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Reinheit: 99.89%
CAS. Nr.: 748119-79-1
Formel: C₁₆H₃₈N₄O₂
Molecular Weight:318.50

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Ivospemin Chemical Structure

CAS. Nr.: 748119-79-1

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Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
L1210	IC₅₀	0.06 μM Compound: (S,S)-(HO)2 DEHSPM	Growth uM after 96 hours Growth uM after 96 hours	[PMID: 10649978]
L1210	IC₅₀	2 μM Compound: (S,S)-(HO)2 DEHSPM	Growth uM after 48 hours Growth uM after 48 hours	[PMID: 10649978]

In Vitro

Ivospemin (500 nM to 10 µM, 96 h) reduces cell viability in human ovarian adenocarcinoma cells with IC₅₀ values ranging between 0.95 µM and 3.24 µM regardless of cisplatin sensitivity^[2].

IC₅₀ values following Ivospemin treatment in human ovarian adenocarcinoma cell lines^[1]

Cell Line	CaOV-3	A2780	OV90	ACRP
Ivospemin 96 h IC₅₀	2.56 µM	0.95 µM	3.24 µM	1.41 µM

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

A2780, OV90, ACRP, and CaOV-3 cell lines
Concentration:

500 nM to 10 µM
Incubation Time:

96 h
Result:

Reduced cell viability in A2780, OV90, ACRP, and CaOV-3 cell lines.

In Vivo

Ivospemin (24 mg/kg, i.p., 2qw×3, alternating weeks for 60 days) increases survival by delaying disease onset and decreasing overall tumor burden in a murine ovarian adenocarcinoma model^[2]^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Murine Ovarian Adenocarcinoma Model^[2]^[3]
Dosage:

24 mg/kg
Administration:

i.p., 2qw×3, alternating weeks for 60 days
Result:

Produced a 20% increase in median survival from 43 days to 52 days post-injection, extended the time to ascites formation to 46.9 days, an increase of 13% combined with Gemcitabine (HY-17026) or Topotecan (HY-13768).

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 748119-79-1
Appearance Solid
Molecular Weight 318.50
Formel C₁₆H₃₈N₄O₂
Color White to off-white
SMILES

CCNCC[C@H](O)CNCCCCNC[C@@H](O)CCNCC
Synonyms

SBP-101
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 20 mg/mL (62.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.1397 mL

15.6986 mL

31.3972 mL

5 mM

0.6279 mL

3.1397 mL

6.2794 mL

10 mM

0.3140 mL

1.5699 mL

3.1397 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2 mg/mL (6.28 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2 mg/mL (6.28 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2 mg/mL (6.28 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. International Nonproprietary Names for Pharmaceutical Substances (INN).

[2]. Holbert CE, et al. The Polyamine Analogue Ivospemin Increases Chemotherapeutic Efficacy in Murine Ovarian Cancer. Biomedicines. 2024 May 23;12(6):1157. [Content Brief]

[3]. Liu TA, et al. The Synergistic Benefit of Combination Strategies Targeting Tumor Cell Polyamine Homeostasis. Int J Mol Sci. 2024 Jul 26;25(15):8173. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.1397 mL	15.6986 mL	31.3972 mL	78.4929 mL
	5 mM	0.6279 mL	3.1397 mL	6.2794 mL	15.6986 mL
	10 mM	0.3140 mL	1.5699 mL	3.1397 mL	7.8493 mL
	15 mM	0.2093 mL	1.0466 mL	2.0931 mL	5.2329 mL
	20 mM	0.1570 mL	0.7849 mL	1.5699 mL	3.9246 mL
	25 mM	0.1256 mL	0.6279 mL	1.2559 mL	3.1397 mL
	30 mM	0.1047 mL	0.5233 mL	1.0466 mL	2.6164 mL
	40 mM	0.0785 mL	0.3925 mL	0.7849 mL	1.9623 mL
	50 mM	0.0628 mL	0.3140 mL	0.6279 mL	1.5699 mL
	60 mM	0.0523 mL	0.2616 mL	0.5233 mL	1.3082 mL

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Ivospemin

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Ivospemin

MCE Bioactive Compound Library

Drug Repurposing Compound Library Plus

Clinical Compound Library Plus

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Ivospemin Related Classifications

HY-132822 Related Classifications