KF38789
Based on 2 publication(s) in Google Scholar
KF38789 is a selective inhibitor of P-selectin-PSGL-1 binding. KF38789 inhibits the binding of U937 cells to immobilized P-selectin immunoglobulin G chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.56%
- CAS. Nr.: 257292-29-8
- Formel: C19H21NO5S
- Molecular Weight:375.44
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Publications Citing Use of MedChemExpress (MCE) KF38789
More
Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | EC50 |
0.56 μM
Compound: 5c
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Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay
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[PMID: 17562361] |
| HCT-116 | GI50 |
0.25 μM
Compound: 5c
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Growth inhibition of human HCT116 cells after 48 hrs
Growth inhibition of human HCT116 cells after 48 hrs
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[PMID: 17562361] |
| T47D | EC50 |
0.41 μM
Compound: 5c
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Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay
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[PMID: 17562361] |
| T47D | GI50 |
0.21 μM
Compound: 5c
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Growth inhibition of human T47D cells after 48 hrs
Growth inhibition of human T47D cells after 48 hrs
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[PMID: 17562361] |
KF38789 inhibits P-selectin-induced superoxide production from human polymorphonuclear cells. Intravenously injected KF38789 significantly inhibits the thioglycollate (TG)-induced accumulation of leukocytes in the mouse peritoneal cavity[1].
KF38789 displays a concentration-dependent inhibition of U937 cell adhesion to immobilized P-selectin-Ig with an IC50 value of 1.97±0.74 μM[1].
KF38789 specifically inhibits P-selectin-dependent cell adhesion and the leukocyte recruitment in mouse peritonitis[1].
KF38789 (5 μM) significantly reduces closure of a 500-μm gap between confluent sheets of Human corneal epithelial (HCE)-T cells over an 8-hr period (by ～40%)[2].
Corneal epithelial cell migration is reduced in the presence of KF38789 (5 μM) [2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Intraperitoneal injection of the P-selectin inhibitor KF38789 (daily intraperitoneal injection of 10mg/kg for 12 days) significantly reduces mechanical allodynia in the facial carrageenan-injected mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice[1]
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Dosage:1 mg/kg
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Administration:Intravenously administrated
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Result:Significantly reduced leukocyte accumulation.
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Animal Model:Twenty-four adult male C57BL/6J (B6) mice, about 6-8 weeks of age and weighing approximately 20-30 g[3]
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Dosage:10 mg/kg, 1 mg/kg, 0.1 mg/kg, 0.01 mg/kg or 0.001 mg/kg
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Administration:Intraperitoneal injection daily for 12 days
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Result:Significantly reduced mechanical allodynia in the facial carrageenan-injected mice.
Chemical Information
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CAS. Nr. 257292-29-8
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Appearance Solid
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Molecular Weight 375.44
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Formel C19H21NO5S
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Color Light yellow to yellow
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SMILES
O=C1OC(C)=CC(O)=C1C2=NCCSC(C2)C3=CC=C(C=C3OC)OC
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (66.59 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (281 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. S Ohta, et al. Inhibition of P-selectin specific cell adhesion by a low molecular weight, non-carbohydrate compound, KF38789. Inflamm Res. 2001 Nov;50(11):544-51. [Content Brief]
[2]. Peter J Gillies, et al. Demonstration of P-selectin expression and potential function in human corneal epithelial cells. Exp Eye Res. 2018 Nov;176:196-206. [Content Brief]
[3]. Kay-Wee Poh, et al. Global gene expression analysis in the mouse brainstem after hyperalgesia induced by facial carrageenan injection--evidence for a form of neurovascular coupling? Pain. 2009 Mar;142(1-2):133-41. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6635 mL | 13.3177 mL | 26.6354 mL | 66.5885 mL |
| 5 mM | 0.5327 mL | 2.6635 mL | 5.3271 mL | 13.3177 mL | |
| 10 mM | 0.2664 mL | 1.3318 mL | 2.6635 mL | 6.6589 mL | |
| 15 mM | 0.1776 mL | 0.8878 mL | 1.7757 mL | 4.4392 mL | |
| 20 mM | 0.1332 mL | 0.6659 mL | 1.3318 mL | 3.3294 mL | |
| 25 mM | 0.1065 mL | 0.5327 mL | 1.0654 mL | 2.6635 mL | |
| 30 mM | 0.0888 mL | 0.4439 mL | 0.8878 mL | 2.2196 mL | |
| 40 mM | 0.0666 mL | 0.3329 mL | 0.6659 mL | 1.6647 mL | |
| 50 mM | 0.0533 mL | 0.2664 mL | 0.5327 mL | 1.3318 mL | |
| 60 mM | 0.0444 mL | 0.2220 mL | 0.4439 mL | 1.1098 mL |
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