Kurarinol
Based on 1 publication(s) in Google Scholar
Kurarinol is a flavanone found in the root of Sophora flavescens. Kurarinol is a competitive tyrosinase inhibitor, with IC50 of 0.1 μM for mushroom tyrosinase.
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- CAS. Nr.: 855746-98-4
- Formel: C26H32O7
- Molecular Weight:456.53
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Kurarinol
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Biologische Aktivität
IC50: 0.1 μM (mushroom tyrosinase)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | EC50 |
44 μg/mL
Compound: Kurarinol
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Antiviral activity against HSV2 in african green monkey Vero cells assessed as virus-induced cytopathic effect after 3 days by MTT assay
Antiviral activity against HSV2 in african green monkey Vero cells assessed as virus-induced cytopathic effect after 3 days by MTT assay
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[PMID: 9868163] |
| Vero | EC50 |
60 μg/mL
Compound: Kurarinol
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Antiviral activity against HSV1 in african green monkey Vero cells assessed as virus-induced cytopathic effect after 3 days by MTT assay
Antiviral activity against HSV1 in african green monkey Vero cells assessed as virus-induced cytopathic effect after 3 days by MTT assay
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[PMID: 9868163] |
Kurarinol manifests relatively low cytotoxic activity (EC50>30 μM)[1].
Kurarinol inhibits production of melanin in S. bikiniensis without affecting the growth of microorganism[1].
Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling (STAT3)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats (120-130g), hypercholesterolemic models[3]
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Dosage:20 mg/kg
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Administration:Oral administration, daily, for 3 days
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Result:Decreased serum TC, TG, and LDL-C levels.
Chemical Information
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CAS. Nr. 855746-98-4
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Molecular Weight 456.53
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Formel C26H32O7
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SMILES
CC([C@H](CCC(C)(O)C)CC(C(O)=C1)=C(O[C@H](C(C=CC(O)=C2)=C2O)CC3=O)C3=C1OC)=C
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Structure Classification
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Initial Source
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Reinheit & Dokumentation
Verweise
[1]. Y B Ryu, et al. Kurarinol, tyrosinase inhibitor isolated from the root of Sophora flavescens. Phytomedicine. 2008 Aug;15(8):612-8. [Content Brief]
[2]. Guangwen Shu, et al. Kurarinol induces hepatocellular carcinoma cell apoptosis through suppressing cellular signal transducer and activator of transcription 3 signaling. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):157-65. [Content Brief]
[3]. Hyun Young Kim, et al. Hypolipidemic effects of Sophora flavescens and its constituents in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. Biol Pharm Bull. 2008 Jan;31(1):73-8. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Kurarinol Related Classifications
HY-122933 Related Classifications
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