MC4171
Based on 2 publication(s) in Google Scholar
MC4171 (compound 34) is a selective KAT8 inhibitor (IC50=8.1 µM). MC4171 has been shown to exhibit moderate micromolar antiproliferative activity in different cancer cell lines, including NSCLC and AML, with potential for studying cancer.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.37%
- CAS. Nr.: 3034769-78-0
- Formel: C21H15N3O3
- Molecular Weight:357.36
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MC4171
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Biologische Aktivität
KAT8[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
33 μM
Compound: 34; MC4171
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Antiproliferative activity against human A549 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
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[PMID: 37155735] |
| HCT-116 | IC50 |
46.6 μM
Compound: 34; MC4171
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Antiproliferative activity against human HCT-116 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
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[PMID: 37155735] |
| HT-29 | IC50 |
54 μM
Compound: 34; MC4171
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Antiproliferative activity against human HT-29 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
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[PMID: 37155735] |
| NCI-H1299 | IC50 |
41.6 μM
Compound: 34; MC4171
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Antiproliferative activity against human NCI-H1299 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H1299 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
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[PMID: 37155735] |
| U-937 | IC50 |
51.7 μM
Compound: 34; MC4171
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Antiproliferative activity against human U-937 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human U-937 cells assessed as cell proliferation inhibition incubated for 72 hrs by MTT assay
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[PMID: 37155735] |
Chemical Information
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CAS. Nr. 3034769-78-0
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Appearance Solid
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Molecular Weight 357.36
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Formel C21H15N3O3
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Color Brown to orange
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SMILES
O=C(O)C1=CC=C(N2N=C(C3=CC=CC=C3)/C(C2=O)=C/C4=CC=CN4)C=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
KAT8-mediated MDH2 lactylation promotes renal cancer progression by enhancing mitochondrial function and stress resistance. [Abstract]2025 Aug 5;322(Pt 1):146571. PMID: 40769364 -
Commun Biol
MOF-mediated H4K16ac is critical for blastocyst formation in sheep by shaping promoter accessibility and transcription. [Abstract]2026 Mar 17;9(1):609. PMID: 41844839
Lösungsmittel & Löslichkeit
DMSO : 25 mg/mL (69.96 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7983 mL | 13.9915 mL | 27.9830 mL | 69.9575 mL |
| 5 mM | 0.5597 mL | 2.7983 mL | 5.5966 mL | 13.9915 mL | |
| 10 mM | 0.2798 mL | 1.3991 mL | 2.7983 mL | 6.9957 mL | |
| 15 mM | 0.1866 mL | 0.9328 mL | 1.8655 mL | 4.6638 mL | |
| 20 mM | 0.1399 mL | 0.6996 mL | 1.3991 mL | 3.4979 mL | |
| 25 mM | 0.1119 mL | 0.5597 mL | 1.1193 mL | 2.7983 mL | |
| 30 mM | 0.0933 mL | 0.4664 mL | 0.9328 mL | 2.3319 mL | |
| 40 mM | 0.0700 mL | 0.3498 mL | 0.6996 mL | 1.7489 mL | |
| 50 mM | 0.0560 mL | 0.2798 mL | 0.5597 mL | 1.3991 mL | |
| 60 mM | 0.0466 mL | 0.2332 mL | 0.4664 mL | 1.1660 mL |
MC4171 Related Classifications
HY-153604 Related Classifications
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