Metapramine
Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel.
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- CAS. Nr.: 21730-16-5
- Formel: C16H18N2
- Molecular Weight:238.33
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
NMDA receptor complex channel[4]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Swiss albino mice[5]
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Dosage:0-20 mg/kg
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Administration:Intraperitoneal injection
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Result:Increased jump latency, threshold voltage, reduction in writhes, and tail flick latency in a dose-dependent manner.
Chemical Information
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CAS. Nr. 21730-16-5
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Molecular Weight 238.33
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Formel C16H18N2
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SMILES
CNC1C2=CC=CC=C2N(C)C3=C(C=CC=C3)C1
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Synonyms
19560 RP
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2(3):219-23. [Content Brief]
[3]. H Dagonneau, et al. [Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]. C R Seances Soc Biol Fil. 1986;180(1):43-8. [Content Brief]
[4]. J M Warter, et al. Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(2):261-70. [Content Brief]
[5]. A Boireau, et al. The antidepressant metapramine is a low-affinity antagonist at N-methyl-D-aspartic acid receptors. Neuropharmacology. 1996;35(12):1703-7. [Content Brief]
[6]. Adina Michael-Titus, et al. Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain. 1987 Dec;31(3):391-400. doi: 10.1016/0304-3959(87)90167-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Metapramine Related Classifications
HY-107031 Related Classifications
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