NK-611
NK-611 (VP 19) is an epipodophyllotoxin derivative. NK-611 induces DNA double-strand breaks by inhibiting topoisomerase II (IC50 = 56 μM). NK-611 does not inhibit microtubule polymerization, thus avoiding the side effects of the parent compound, Podofilox (HY-15552). NK-611 exhibits broad-spectrum antitumor activity and demonstrates potent efficacy in in vivo models of leukemia. NK-611 can be used in cancer research.
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- CAS. Nr.: 105655-99-0
- Formel: C31H37NO12
- Molecular Weight:615.62
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Topoisomerase II 56 μM (IC50) |
NK-611 (0.51-51 μM, 1 h- 28 d) exhibits potent cytotoxicity against L1210 cells with an IC50 of 0.33 μM and also exhibits time-dependent broad-spectrum anti-tumor activity against 17 different types of tumors, including renal cell carcinoma and colorectal cancer[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 105655-99-0
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Molecular Weight 615.62
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Formel C31H37NO12
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SMILES
O=C1[C@]2([H])[C@H](C3=CC(OC)=C(O)C(OC)=C3)C4=CC(OCO5)=C5C=C4[C@@H](O[C@@]6([H])[C@@H]([C@H]([C@@]7([H])[C@](CO[C@@H](C)O7)([H])O6)O)N(C)C)[C@@]2([H])CO1
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Synonyms
VP 19
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Daley L, et al. Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611. J Med Chem. 1998 Nov 5;41(23):4475-85. [Content Brief]
[2]. Hanauske AR, et al. Activity of NK 611, a new epipodophyllotoxin derivative, against colony forming units from freshly explanted human tumours in vitro. Eur J Cancer. 1995 Sep;31A(10):1677-81. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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