NSC 1008
NSC 1008 is a selective Ras converting enzyme 1 (Rce1) inhibitor that reduces Rce1 in vitro activity with a human IC50 of 8.9 μM. NSC 1008 demonstrates selectivity for Rce1 by not inhibiting human Ste24 or huamn FTase. NSC 1008 exhibits low cell toxicity, and induces mislocalization of EGFP-Ras from the plasma membrane in cancer cells. NSC 1008 can be used for the research of cancer.
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- CAS. Nr.: 5335-95-5
- Formel: C22H18N2O
- Molecular Weight:326.40
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U-87MG ATCC | IC50 |
>10 μM
Compound: NC266, NSC 1008
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Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 32830969] |
| U-87MG ATCC | IC50 |
10 μM
Compound: NC266, NSC 1008
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Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against human U-87 MG cells assessed as growth inhibition measured after 72 hrs by MTT assay
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[PMID: 32830969] |
NSC 1008 (compound 2) inhibits human Rce1 activity (IC50 = 8.9 μM)[1].
NSC 1008 (25 µM; 20 hours) exhibits low toxicity in HCT-116 cells[1].
NSC 1008 (25 µM; 20 hours) induces mislocalization of EGFP-H-Ras, EGFP-N-Ras, and EGFP-K-Ras4b in HCT-116 cells[1].
NSC 1008 (10-50 µM) demonstrates selectivity for Rce1 by not inhibiting human Ste24 or huamn FTase[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116 human colon carcinoma cells
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Concentration:25 μM
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Incubation Time:20-hour treatment; 4-hour reagent incubation
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Result:Caused minimal cell death (less than 10%) compared to DMSO-treated and untreated cells.
Chemical Information
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CAS. Nr. 5335-95-5
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Appearance Solid
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Molecular Weight 326.40
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Formel C22H18N2O
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SMILES
OC=1C2=NC=CC=C2C=CC1C(NC=3C=CC=CC3)C=4C=CC=CC4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NSC 1008 Related Classifications
HY-124126 Related Classifications
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