NSC727447
Based on 1 Customer Validation
NSC727447 is an inhibitor of ribonuclease H (Rnase H) of HIV-1 and HIV-2. NSC727447 has little activity against E. coli RNase H, but great selectivity over human Rnase H, with IC50s value of 2.0 μM, 2.5 μM, 100 μM, 10.6 μM, respectively.
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- Reinheit: 95.0%
- CAS. Nr.: 40106-12-5
- Formel: C10H14N2OS
- Molecular Weight:210.30
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Speicherung:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CEM-SS | CC50 |
19.9 μM
Compound: 1
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Cytotoxicity against human CEM-SS cells by XTT assay
Cytotoxicity against human CEM-SS cells by XTT assay
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[PMID: 20547794] |
| CEM-SS | IC50 |
4.3 μM
Compound: 1
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Antiviral activity against HIV-1 isolate RF infected in human CEM-SS cells assessed as inhibition of virus induced cytopathic effect by XTT assay
Antiviral activity against HIV-1 isolate RF infected in human CEM-SS cells assessed as inhibition of virus induced cytopathic effect by XTT assay
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[PMID: 20547794] |
Chemical Information
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CAS. Nr. 40106-12-5
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Appearance Solid
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Molecular Weight 210.30
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Formel C10H14N2OS
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Color Light brown to brown
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SMILES
O=C(C1=C(N)SC2=C1CCCCC2)N
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Lösungsmittel & Löslichkeit
DMSO : 50 mg/mL (237.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.7551 mL | 23.7756 mL | 47.5511 mL | 118.8778 mL |
| 5 mM | 0.9510 mL | 4.7551 mL | 9.5102 mL | 23.7756 mL | |
| 10 mM | 0.4755 mL | 2.3776 mL | 4.7551 mL | 11.8878 mL | |
| 15 mM | 0.3170 mL | 1.5850 mL | 3.1701 mL | 7.9252 mL | |
| 20 mM | 0.2378 mL | 1.1888 mL | 2.3776 mL | 5.9439 mL | |
| 25 mM | 0.1902 mL | 0.9510 mL | 1.9020 mL | 4.7551 mL | |
| 30 mM | 0.1585 mL | 0.7925 mL | 1.5850 mL | 3.9626 mL | |
| 40 mM | 0.1189 mL | 0.5944 mL | 1.1888 mL | 2.9719 mL | |
| 50 mM | 0.0951 mL | 0.4755 mL | 0.9510 mL | 2.3776 mL | |
| 60 mM | 0.0793 mL | 0.3963 mL | 0.7925 mL | 1.9813 mL | |
| 80 mM | 0.0594 mL | 0.2972 mL | 0.5944 mL | 1.4860 mL | |
| 100 mM | 0.0476 mL | 0.2378 mL | 0.4755 mL | 1.1888 mL |
NSC727447 Related Classifications
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