NSS-18
NSS-18 is a potent and reversible inhibitor of AChE and MAO-B, with IC50 values of 1.53 and 1.51 μM respectively. NSS-18 can inhibit the self-aggregation of Aβ. NSS-18 inhibits the intracellular generation of ROS induced by Aβ. NSS-18 shows a moderate neuroprotective effect against 6-OHDA (HY-B1081)-induced neurotoxicity. NSS-18 can form chelates with metal ions such as Cu²⁺, Fe³⁺, and Zn²⁺, with the strongest chelation being with Cu²⁺. NSS-18 can be used for the study of Alzheimer's disease.
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- Formel: C24H23NO5
- Molecular Weight:405.44
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
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AChE 1.53 μM (IC50) |
MAO-B 1.51 μM (IC50) |
Chemical Information
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Molecular Weight 405.44
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Formel C24H23NO5
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SMILES
O=C1C(O)=C(C2=CC=C(OCCN3CCCC3)C=C2)OC4=CC(OCC#C)=CC=C41
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
NSS-18 Related Classifications
HY-180114 Related Classifications
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- NSS-18
- NSS18
- NSS 18
- Cholinesterase (ChE)
- Monoamine Oxidase
- Amyloid-β
- Reactive Oxygen Species (ROS)
- Alzheimer's disease
- Monoamine oxidase
- 3-Hydroxy chromones
- Multipotent drugs
- Chromone derivatives
- Multi-target directed ligands
- MAO-B inhibitors
- Aβ aggregation
- Molecular docking
- Molecular dynamics
- Fluorescence properties
- Inhibitor
- inhibitor
- inhibit