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Art. -Nr.: HY-P991016

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Biologically Validated

Peluntamig

(Synonyms: PT-217)

Kundenbewertung

Based on 1 Customer Validation

Peluntamig (PT-217) is a bispecific antibody targeting DLL3 and CD47. The antibody arms of Peluntamig specifically bind to DLL3 on small cell lung cancer tumor cells while blocking the CD47-SIRPa interaction, thereby effectively stimulating macrophage phagocytosis and inducing NK cell-mediated cytotoxicity. Peluntamig exhibits significant anti-tumor activity against small cell lung cancer and also has favorable safety profiles. Peluntamig can be used in a variety of tumor-related studies including those on small cell lung cancer and L1210 leukemia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.9%
CAS. Nr.: 2928515-21-1
Molecular Weight:145.027 kDa

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Peluntamig Chemical Structure

CAS. Nr.: 2928515-21-1

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Verified Bioactivity
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

CD47 & DLL3

In Vivo

Peluntamig (15 mg/kg; i.p.; single injection) combined with cyclophosphamide and 5-fluorouracil (HY-90006) produces a highly significant enhancement in % ILS and a 70% cure rate in BDF₁ mice with advanced L1210 leukemia^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 × DBA/2 F₁ (BDF₁) (male, injected intraperitoneally with 10⁶ L1210 leukemia cells on day 0)^[2]
Dosage:

15 mg/kg
Administration:

i.p.; single injection; day 3 post-tumor cell inoculation
Result:

Produced a percent increase in life span (% ILS) that contributed to an additive predicted % ILS for the triple combination (Peluntamig+cyclophosphamide + 5-fluorouracil).
Yielded an observed % ILS significantly exceeding the additive predicted value (p < 0.001) when used in the triple combination.
Resulted in 7 cures (≥60-day survival) out of 10 treated mice in the triple combination.
Caused a +2% mean weight change 5 days post-treatment when administered alone.
Caused a -9% mean weight change 5 days post-treatment in the triple combination.
Led to no toxic deaths in any treatment group.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

16423 [NCBI] & 10683 [NCBI]

Accession

Q61735-1 & Q9NYJ7

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG1-kappa

Anwendung

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Delta-like protein 3/DLL3 Protein, Human (HEK293, His, HY-P700456) can bind Peluntamig. The EC₅₀ for this effect is 19.78 ng/mL.
Immobilized CD47 Protein, Human (HEK293, His, HY-P7336) can bind Peluntamig. The EC₅₀ for this effect is 187.6 ng/mL.

Chemical Information

CAS. Nr. 2928515-21-1
Appearance Liquid
Molecular Weight 145.027 kDa
Color Colorless to light yellow
SMILES

[Peluntamig]
Synonyms

PT-217
Versand

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Verweise

[1]. Corica D A, Bell S D, Zhao L, et al. The Era of Precision Medicine: Advancing Treatment Paradigms for Small Cell Lung Cancer[J]. Cancers, 2025, 17(11): 1847.

[2]. Gale G R, Atkins L M, Schwartz P, et al. Potentiating action of 5-fluorouracil when used in combination with platinum compounds and cyclophosphamide in treatment of advanced L1210 leukemia[J]. Bioinorganic Chemistry, 1978, 8(5): 445-451.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Angebot einholen Auf Lager

Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vivo
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- Anwendung
- Biological Activity
Chemical Information
Reinheit & Dokumentation
Verweise

1/16

IgG1-kappa
1/16

Immobilized Delta-like protein 3/DLL3 Protein, Human (HEK293, His, HY-P700456) can bind Peluntamig. The EC₅₀ for this effect is 19.78 ng/mL.
1/16

Immobilized CD47 Protein, Human (HEK293, His, HY-P7336) can bind Peluntamig. The EC₅₀ for this effect is 187.6 ng/mL.
1/16

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Peluntamig

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Antibody Inhibitor Library

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Peluntamig Related Classifications

HY-P991016 Related Classifications