PMEG
PMEG is a nuclear DNA polymerases α, δ, and ε inhibitor that causes DNA chain termination, inhibits DNA synthesis, induces cytotoxicity in dividing cells. PMEG is an acyclic nucleotide phosphonate that forms an active phosphorylated metabolite, PMEG diphosphate, within cells. PMEG has activity against leukemia and melanoma in rodent models. PMEG has poor cell permeability; its prodrug is Rabacfosadine (GS-9219) (HY-13640). PMEG shows antiviral activity against against various DNA virus infections including murine cytomegalovirus (MCMV) and human cytomegalovirus (HCMV). PMEG can be used for the research of non-hodgkin's lymphoma[1][2].
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- CAS. Nr.: 114088-58-3
- Formel: C8H12N5O5P
- Molecular Weight:289.19
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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DNA Polymerase |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Ca-Ski | EC50 |
5530 nM
Compound: PMEG
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Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay
Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay
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[PMID: 19398642] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 114088-58-3
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Molecular Weight 289.19
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Formel C8H12N5O5P
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SMILES
O=C1N=C(NC2=C1N=CN2CCOCP(O)(O)=O)N
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Synonyms
9-(2-Phosphonylmethoxy)ethylguanine
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Kim HT, et al. Antiviral activity of 9-[[(ethoxyhydroxyphosphinyl)-methoxy]methoxy] guanine against cytomegalovirus and herpes simplex virus. Antiviral Res. 1995 Nov;28(3):243-51. [Content Brief]
[2]. Vail DM, et al. Assessment of GS-9219 in a pet dog model of non-Hodgkin's lymphoma. Clin Cancer Res. 2009;15(10):3503-3510. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
PMEG Related Classifications
HY-185150 Related Classifications
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- PMEG
- 114088-58-3
- 9-(2-Phosphonylmethoxy)ethylguanine
- DNA/RNA Synthesis
- CMV
- lymphoid cells
- DNA synthesis
- dividing cells
- leukemia
- rodent models
- client-owned pet dogs
- cytotoxicity
- anticancer agent
- ε
- high-proliferation lymphoid malignancies
- non-hodgkin's lymphoma
- spontaneous non-Hodgkin's lymphoma
- nuclear DNA polymerases α
- δ
- DNA chain termination
- melanoma
- Inhibitor
- inhibitor
- inhibit