Pralidoxime
Based on 3 publication(s) in Google Scholar
Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning.
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- CAS. Nr.: 6735-59-7
- Formel: C7H9N2O+
- Molecular Weight:137.16
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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- Verweise
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Publications Citing Use of MedChemExpress (MCE) Pralidoxime
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Biologische Aktivität
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AChE |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:F1B6D2 mice (male, administered subcutaneously diethylparaoxon)[3]
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Dosage:10, 50, 100, and 150 mg/kg
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Administration:Intramuscular administration, once
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Result:Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 6735-59-7
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Appearance Solid
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Molecular Weight 137.16
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Formel C7H9N2O+
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Color Light yellow to yellow
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SMILES
C[N+]1=CC=CC=C1/C=N/O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [Content Brief]
[2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [Content Brief]
[3]. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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