Art. -Nr.: HY-108009A

Rezafungin acetate

(Synonyms: Biafungin acetate; CD101 acetate; SP-3025 acetate)

4 Cited Publications

Kundenbewertung

Based on 4 publication(s) in Google Scholar

Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp..

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Reinheit: 99.84%
CAS. Nr.: 1631754-41-0
Formel: C₆₅H₈₈N₈O₁₉
Molecular Weight:1285.44

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Rezafungin acetate Chemical Structure

CAS. Nr.: 1631754-41-0

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Biologische Aktivität
- Beschreibung
- In Vivo
Chemical Information
Publications (4)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vivo

Rezafungin acetate (Biafungin acetate) (1 mg/kg; i.p. once daily for 6 days) shows potent in vivo efficacy as prophylaxis against Pneumocystis in a mouse infection model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C3H/HeN mice^[1]
Dosage:

1 mg/kg
Administration:

Intraperitoneal injection; once daily for 6 days
Result:

Significantly reduced nuclei and asci burdens.

Chemical Information

CAS. Nr. 1631754-41-0
Appearance Solid
Molecular Weight 1285.44
Formel C₆₅H₈₈N₈O₁₉
Color White to off-white
SMILES

O=C1N2[C@]([C@@H](O)[C@@H](C)C2)([H])C(N[C@]([C@@H](C[C@@H](C(N[C@]([C@H](O)C)([H])C(N3[C@](C[C@@H](O)C3)([H])C(N[C@]([C@H](O)[C@H](C4=CC=C(O)C=C4)O)([H])C(N[C@@]1([H])[C@H](O)C)=O)=O)=O)=O)NC(C5=CC=C(C6=CC=C(C7=CC=C(OCCCCC)C=C7)C=C6)C=C5)=O)O)([H])OCC[N+](C)(C)C)=O.[O-]C(C)=O
Synonyms

Biafungin acetate; CD101 acetate; SP-3025 acetate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (4)

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Journal Impact Factor

J Fungi (Basel)

In Vitro Activitiy of Rezafungin in Comparison with Anidulafungin and Caspofungin against Invasive Fungal Isolates (2017 to 2022) in China. [Abstract]

2024 May 31;10(6):397. PMID: 38921383
Antimicrob Agents Chemother

Candida parapsilosis and echinocandins: should the clinical laboratory drop anidulafungin Etest from the susceptibility testing panel?. [Abstract]

2025 Aug 6;69(8):e0024125. PMID: 40590712
Microbiol Spectr

Multicenter surveillance of antifungal susceptibility of clinical Aspergillus isolates to conventional and novel antifungal agents in Taiwan, 2021-2023. [Abstract]

2026 Apr 21:e0265925. PMID: 42012212
Preprints

2023 May 17.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 200 mg/mL (155.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

0.7779 mL

3.8897 mL

7.7794 mL

5 mM

0.1556 mL

0.7779 mL

1.5559 mL

10 mM

0.0778 mL

0.3890 mL

0.7779 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (3.89 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (3.89 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (3.89 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Melanie Cushion, et al. Rezafungin Prophylactic Efficacy in a Mouse Model of Pneumocystis Pneumonia. VOLUME 25, ISSUE 3, SUPPLEMENT, S366, MARCH 01, 2019.

[2]. Sofjan AK, et al. Rezafungin (CD101), a next-generation echinocandin: A systematic literature review and assessment of possible place in therapy. J Glob Antimicrob Resist. 2018 Sep;14:58-64. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	0.7779 mL	3.8897 mL	7.7794 mL	19.4486 mL
	5 mM	0.1556 mL	0.7779 mL	1.5559 mL	3.8897 mL
	10 mM	0.0778 mL	0.3890 mL	0.7779 mL	1.9449 mL
	15 mM	0.0519 mL	0.2593 mL	0.5186 mL	1.2966 mL
	20 mM	0.0389 mL	0.1945 mL	0.3890 mL	0.9724 mL
	25 mM	0.0311 mL	0.1556 mL	0.3112 mL	0.7779 mL
	30 mM	0.0259 mL	0.1297 mL	0.2593 mL	0.6483 mL
	40 mM	0.0194 mL	0.0972 mL	0.1945 mL	0.4862 mL
	50 mM	0.0156 mL	0.0778 mL	0.1556 mL	0.3890 mL
	60 mM	0.0130 mL	0.0648 mL	0.1297 mL	0.3241 mL
	80 mM	0.0097 mL	0.0486 mL	0.0972 mL	0.2431 mL
	100 mM	0.0078 mL	0.0389 mL	0.0778 mL	0.1945 mL

Keywords

Rezafungin acetate

4 Cited Publications

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Rezafungin acetate

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Publications Citing Use of MedChemExpress (MCE) Rezafungin acetate

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Rezafungin acetate

Anti-Infection Compound Library

FDA-Approved Drug Library

Drug Repurposing Compound Library

Macrocyclic Compound Library

Antifungal Compound Library

FDA Approved & Pharmacopeial Drug Library

Rare Diseases Drug Library

Heterocyclic Compound Library

Off-patent Drug Library

Bioactive Compound Library Max

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Rezafungin acetate

Biologische Aktivität

Chemical Information

Publications (4)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Rezafungin acetate Related Classifications

HY-108009A Related Classifications