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Sirukumab

(Synonyms: CNTO-136)
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Sirukumab (CNTO-136) is a humanized monoclonal anti-IL6 (Interleukin Related) IgG1κ antibody. Sirukumab binds to IL6, preventing IL6-mediated signal transduction and activation of transcriptional activators, thereby blocking the downstream biological effects of IL6. Sirukumab can be used in the study of active lupus nephritis and rheumatoid arthritis.

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  • Reinheit: 96.83%
  • CAS. Nr.: 1194585-53-9
  • Molecular Weight:144.58 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Sirukumab
  • Experimental Validation Results for Sirukumab
  • Experimental Validation Results for Sirukumab
  • Sirukumab Chemical Structure
    Sirukumab Chemical Structure
CAS. Nr.: 1194585-53-9
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Sirukumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human IL-6 Protein can bind Sirukumab. The EC50 for this effect is 1.86 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 Siha cells labeling Sirukumab (HY-P99316, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Sirukumab Chemical Structure
    1/16
  • Sirukumab
  • Immobilized Human IL-6 Protein can bind Sirukumab. The EC50 for this effect is 1.86 ng/mL.
  • Flow cytometric analysis of 1.5×106 Siha cells labeling Sirukumab (HY-P99316, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).