STAT5-IN-3
STAT5-IN-3 (Compound 14a) is a STAT5 inhibitor with anticancer activity. STAT5-IN-3 blocks the tyrosine phosphorylation of STAT5A/5B at the Y694/699 sites and significantly reduces the expression of STAT5B protein, thereby inhibiting downstream gene transcription and blocking the proliferation and survival of leukemia cells. Additionally, STAT5-IN-3 holds significant value in overcoming chemotherapy resistance.
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- Formel: C25H27N5O
- Molecular Weight:413.51
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
STAT5-IN-3 (Compound 14a) (100 nM-10 μM; 48 h) can inhibit the activity of myeloid leukemia cells (KU812, K562, KCL-22, MV-4-11, and MOLM-13) with EC50 values of 0.6 μM, 0.8 μM, 0.5 μM, 0.3 μM, and 0.3 μM, respectively. In contrast, STAT5-IN-3 exhibits low toxicity towards normal cells (HS27A and MSC), with EC50 values exceeding 10 μM for both cell types[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 413.51
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Formel C25H27N5O
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SMILES
CC(CC1)(C)C2=C(C=CC=C2C3=CN=C(N)N=C3)N1CCOC4=CC=C5C(C=CN5)=C4
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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