TC4
TC4 is a highly balanced single-molecule quadruple agonist that can respectively activate GIPR, GLP-1R, GcgR, and Y2R with IC50 values of 0.95, 31, 81, and 1100 nM respectively. TC4 exhibits extremely strong signal bias on GLP-1R and has very low recruitment efficacy for β-inhibitor protein 2 (βArr2) and this strong cAMP preference is believed to maximize metabolic benefits (such as weight loss and hypoglycemia) while possibly minimizing side effects mediated by β-inhibitor protein recruitment (such as receptor desensitization). TC4 can be used for research on obesity and diabetes.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Formel: C277H423N69O78
- Molecular Weight:5967.74
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
Chemical Information
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Molecular Weight 5967.74
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Formel C277H423N69O78
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Sequence
Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Leu-Leu-Asp-Arg-Lys(βAla-AEEA-γGlu-C18 diacid)-Ala-Gln-Ala-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Leu-Arg-His-Tyr-Val-Asn-Trp-Leu-Thr-Arg-Gln-Arg-Tyr-NH2
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Sequence Shortening
Y-{Aib}-QGTFTSDYSILLDR-Lys(βAla-AEEA-γGlu-C18 diacid)-AQAAFIEYLLEGGPSLRHYVNWLTRQRY-NH2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
TC4 Related Classifications
HY-P11275 Related Classifications
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