Vindesine
Vindesine is a derivative of Vinblastine (HY-13780). Vindesine binds to and stabilizes tubulin. Vindesine inhibits mitosis in cancer cells and prevents the invasion of normal tissues by malignant cells. Vindesine can be used in cancer research.
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- CAS. Nr.: 53643-48-4
- Formel: C43H55N5O7
- Molecular Weight:753.93
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Vindesine binds to intracellular tubulin, thereby inhibiting the assembly of functional microtubules in actively dividing cells[2].
Vindesine potently inhibits mitosis in cancer cell lines[3].
Vindesine inhibits the invasion of malignant cells into normal tissues in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 53643-48-4
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Molecular Weight 753.93
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Formel C43H55N5O7
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SMILES
CN([C@]1([H])[C@@]23[C@]4([H])[C@](C=CCN4CC3)(CC)[C@@H](O)[C@]1(O)C(N)=O)C(C2=C5)=CC(OC)=C5[C@](C[C@]6([H])C[N@]7C[C@@](CC)(O)C6)(C(OC)=O)C8=C(CC7)C9=CC=CC=C9N8
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Gökbuget N, et al. Vindesine in the treatment of leukaemia. Leuk Lymphoma. 1997;26(5-6):497-506. [Content Brief]
[2]. Sørensen JB, et al. Is there a role for vindesine in the treatment of non-small cell lung cancer?. Invest New Drugs. 1993;11(2-3):103-133. [Content Brief]
[3]. Dhyani P, et al. Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int. 2022;22(1):206. Published 2022 Jun 2. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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