Ganoderic acid B
Based on 1 Customer Validation
Ganoderic acid B is a triterpene isolated from a mushroom Ganoderma lucidum. Ganoderic acid B inhibits the activation of Epstein-Barr virus (EBV) antigens as telomerase inhibitor. Ganoderic acid B is a moderately active inhibitor against HIV-1 protease (IC50: 170 μM).
For research use only. We do not sell to patients.
- Purity : 99.60%
- CAS No.: 81907-61-1
- Formula: C30H44O7
- Molecular Weight:516.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Ganoderic acid B (Standard)HIV Protease Inhibitor -
HY-N0038
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TelocinobufaginAnticancer Agent -
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HinokininHIV-1 Inhibitor -
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Escin IALOXL2 Inhibitor, EMT Inhibitor
Biological Activity
Description
IC50 & Target
HIV-1 protease[3]
In Vitro
In Vivo
Ganoderic acid B (5 mg/kg, s.c.) shows antinociceptive effects in acetic acid-induced writhing in mice[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:LPS-induced pneumonia mice[4]
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Dosage:3 or 6 mg/kg
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Administration:i.p.
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Result:Reduced Lung dry/wet weight (W/D) and myeloperoxidase activity in lung.
Increased SOD, decreased MDA, TNF-α, IL-1β and IL-6 level.
Chemical Information
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CAS No. 81907-61-1
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Appearance Solid
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Molecular Weight 516.67
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Formula C30H44O7
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Color White to light brown
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SMILES
C[C@]([C@@]([C@]([C@H](C)CC(C[C@@H](C)C(O)=O)=O)([H])C1)(CC2=O)C)(C1=O)C([C@H](C[C@@]3([H])C4(C)C)O)=C2[C@]3(CC[C@@H]4O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (96.77 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Zhou S, et al. Triterpenes and Soluble Polysaccharide Changes in Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), During Fruiting Growth. Int J Med Mushrooms. 2018;20(9):859-871. [Content Brief]
[2]. Zheng DS, et al. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Exp Ther Med. 2017 Oct;14(4):3273-3278. [Content Brief]
[3]. el-Mekkawy S, et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry. 1998 Nov;49(6):1651-7. [Content Brief]
[4]. Shi J, et al. Ganoderic acid B attenuates LPS-induced lung injury. Int Immunopharmacol. 2020 Nov;88:106990. [Content Brief]
[5]. Koyama K, et al. Antinociceptive components of Ganoderma lucidum. Planta Med. 1997 Jun;63(3):224-7. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9355 mL | 9.6774 mL | 19.3547 mL | 48.3868 mL |
| 5 mM | 0.3871 mL | 1.9355 mL | 3.8709 mL | 9.6774 mL | |
| 10 mM | 0.1935 mL | 0.9677 mL | 1.9355 mL | 4.8387 mL | |
| 15 mM | 0.1290 mL | 0.6452 mL | 1.2903 mL | 3.2258 mL | |
| 20 mM | 0.0968 mL | 0.4839 mL | 0.9677 mL | 2.4193 mL | |
| 25 mM | 0.0774 mL | 0.3871 mL | 0.7742 mL | 1.9355 mL | |
| 30 mM | 0.0645 mL | 0.3226 mL | 0.6452 mL | 1.6129 mL | |
| 40 mM | 0.0484 mL | 0.2419 mL | 0.4839 mL | 1.2097 mL | |
| 50 mM | 0.0387 mL | 0.1935 mL | 0.3871 mL | 0.9677 mL | |
| 60 mM | 0.0323 mL | 0.1613 mL | 0.3226 mL | 0.8064 mL | |
| 80 mM | 0.0242 mL | 0.1210 mL | 0.2419 mL | 0.6048 mL |
Ganoderic acid B Related Classifications
HY-N2006 Related Classifications
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