2. Inhibitory Antibodies
  3. Atacicept

Atacicept  (Synonyms: TACI-Ig; TACI-Fc 5)

Cat. No.: HY-P99446 Purity: 99.50%
COA

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Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease.

For research use only. We do not sell to patients.

Atacicept Chemical Structure

Atacicept Chemical Structure

CAS No. : 845264-92-8

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Description

Atacicept (TACI-Ig) is a is a recombinant fusion protein containing the extracellular, ligand-binding portion of the TACI receptor and the Fc portion of human IgG. Atacicept inhibits B cell stimulation by binding to B lymphocyte stimulator and a proliferation-inducing ligand. Atacicept can be used in research of B-cell autoimmune disease[1][2].

In Vivo

Atacicept (TACI-Ig; 100 μg; i.p.; three times of week for 14 days; BALB/c mice) reduces mature B-cell counts and serum antibody levels in normal mice[1].
Atacicept (TACI-Ig) inhibits the progression of disease and autoantibody titers in a mouse model of collagen-induced arthritis (CIA)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male DBA/1 mice with CIA models[1]
Dosage: 100 μg
Administration: intraperitoneal injection; three times of week for 21 days
Result: Increased serum titers of anti-collagen Abs and few overt signs of disease.
Animal Model: BALB/c mice[1]
Dosage: 100 μg
Administration: intraperitoneal injection; three times of week for 14 days
Result: Reduced mature B cell populations but had little effect on other cell lineages.
Blocked the development of B cells at the transition from T1 to T2 and the development of MZ B cells in the spleen.
Decerased the serum levels of IgM about 2.3-fold.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Atacicept]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.50%

COA (231 KB)

Handling Instructions (2659 KB)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atacicept845264-92-8TACI-Ig TACI-Fc 5Othersrecombinant fusion proteinTACI receptorFc IgGB cellautoimmuneInhibitorinhibitorinhibit

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