ATR-IN-1
ATR-IN-1 is a selective ATR inhibitor with an IC50 of 0.5 nM. ATR-IN-1 inhibits the growth of ATM-deficient melanoma. ATR-IN-1 shows no hERG inhibitory effect. ATR-IN-1 can be used for research on melanoma.
For research use only. We do not sell to patients.
- CAS No.: 1639974-69-8
- Formula: C18H19N7O
- Molecular Weight:349.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
ATR 0.5 nM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-144 | GI50 |
0.35 μM
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Inhibition of growth of ATM-null human HT144 melanoma cells after 72 hrs continuous exposure measured by CellTiter-Glo assay.
Inhibition of growth of ATM-null human HT144 melanoma cells after 72 hrs continuous exposure measured by CellTiter-Glo assay.
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25589928 |
In Vitro
ATR-IN-1 (Compound 13) inhibits ATR with an IC50 of 0.0005 µM and shows selectivity over ATM (IC50 15 µM) and DNAPK (IC50 >25 µM)[1].
ATR-IN-1 (1 h) does not inhibit mTOR signaling in TSC1−/− MEF cells (IC50 >13 µM)[1].
ATR-IN-1 has a hERG IC50 >30 µM by automated whole-cell electrophysiology[1].
ATR-IN-1 does not inhibit CYP3A4, 2D6, 2C9, or 1A2 (IC50 >24 µM)[1].
ATR-IN-1 (72 h) inhibits the growth of ATM-null HT144 melanoma cells with a GI50 of 0.35 µM after 72 h continuous exposure[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1639974-69-8
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Molecular Weight 349.40
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Formula C18H19N7O
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SMILES
C[C@H]1N(C2=C3C(=CC(=N2)C4=C5C(NC=C5)=CN=N4)N(C)C=N3)CCOC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATR-IN-1 Related Classifications
HY-12924 Related Classifications
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