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Art. -Nr.: HY-12924

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ATR-IN-1

ATR-IN-1 is a selective ATR inhibitor with an IC₅₀ of 0.5 nM. ATR-IN-1 shows no hERG inhibitory effect. ATR-IN-1 inhibits the growth of ATM-deficient melanoma.

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CAS. Nr.: 1639974-69-8
Formel: C₁₈H₁₉N₇O
Molecular Weight:349.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ATR-IN-1 Chemical Structure

CAS. Nr.: 1639974-69-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ATR-IN-1 is a selective ATR inhibitor with an IC₅₀ of 0.5 nM. ATR-IN-1 shows no hERG inhibitory effect. ATR-IN-1 inhibits the growth of ATM-deficient melanoma^[1].

IC₅₀ & Target

^[1]

ATR

0.5 nM (IC₅₀)

Alle ATM/ATR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-144	GI50	0.35 μM	Inhibition of growth of ATM-null human HT144 melanoma cells after 72 hrs continuous exposure measured by CellTiter-Glo assay. Inhibition of growth of ATM-null human HT144 melanoma cells after 72 hrs continuous exposure measured by CellTiter-Glo assay.	25589928

In Vitro

ATR-IN-1 (Compound 13) inhibits ATR with an IC₅₀ of 0.0005 µM and shows selectivity over ATM (IC₅₀ 15 µM) and DNAPK (IC₅₀ >25 µM)^[1].
ATR-IN-1 (1 h) does not inhibit mTOR signaling in TSC1^−/− MEF cells (IC₅₀ >13 µM)^[1].
ATR-IN-1 has a hERG IC₅₀ >30 µM by automated whole-cell electrophysiology^[1].
ATR-IN-1 does not inhibit CYP3A4, 2D6, 2C9, or 1A2 (IC₅₀ >24 µM)^[1].
ATR-IN-1 (72 h) inhibits the growth of ATM-null HT144 melanoma cells with a GI₅₀ of 0.35 µM after 72 h continuous exposure^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 1639974-69-8
Molecular Weight 349.40
Formel C₁₈H₁₉N₇O
SMILES

C[C@H]1N(C2=C3C(=CC(=N2)C4=C5C(NC=C5)=CN=N4)N(C)C=N3)CCOC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Barsanti PA, et al. Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors. ACS medicinal chemistry letters. 2015 Jan 08;6(1):42-6.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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