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Cat. No.: HY-146889

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ATX inhibitor 16

ATX inhibitor 16 is a potent ATX inhibitor with an IC₅₀ of 0.0021 μM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells.

For research use only. We do not sell to patients.

CAS No.: 2484811-36-9
Formula: C₂₈H₂₇F₃N₆OS₂
Molecular Weight:584.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

ATX inhibitor 16 Chemical Structure

CAS No.: 2484811-36-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ATX inhibitor 16 is a potent ATX inhibitor with an IC₅₀ of 0.0021 μM. ATX inhibitor 16 shows excellent anti-proliferative activities in breast cancer cells^[1].

IC₅₀ & Target

IC₅₀: 0.0021 µM (ATX)^[1]

All Phosphodiesterase (PDE) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	10.98 μM Compound: 9j	Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay Antiproliferative activity against human A549 cells measured after 72 hrs by MTT assay	[PMID: 32535330]
MCF7	IC₅₀	0.43 μM Compound: 9j	Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells measured after 72 hrs by MTT assay	[PMID: 32535330]
MDA-MB-231	IC₅₀	0.31 μM Compound: 9j	Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by MTT assay	[PMID: 32535330]
NCI-H2228	IC₅₀	7.18 μM Compound: 9j	Antiproliferative activity against human NCI-H2228 cells measured after 72 hrs by MTT assay Antiproliferative activity against human NCI-H2228 cells measured after 72 hrs by MTT assay	[PMID: 32535330]

In Vitro

ATX inhibitor 16 (compound 9j) (0-15 μM; 72 h) shows excellent anti-proliferative activities in breast cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

MCF7, MDA-MB-231, A549, H2228 cells
Concentration:

0-15 µM
Incubation Time:

72 h
Result:

Exhibited excellent anti-proliferative activities with IC₅₀s of 0.43, 0.31, 10.98, 7.18 µM for MCF7, MDA-MB-231, A549, H2228 cells, respectively.

Chemical Information

CAS No. 2484811-36-9
Molecular Weight 584.68
Formula C₂₈H₂₇F₃N₆OS₂
SMILES

OC1CCN(CC2=CSC(C3=CC4=C(N(CC)C=C4/C(C(F)(F)F)=N/NC5=NC6=CC=CC=C6S5)C=C3)=N2)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lei H,et al. Structure guided design of potent indole-based ATX inhibitors bearing hydrazone moiety with tumor suppression effects. Eur J Med Chem. 2020 Sep 1;201:112456. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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ATX inhibitor 16

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ATX inhibitor 16 Related Classifications

HY-146889 Related Classifications