ATX inhibitor 18
ATX inhibitor 18 is a potent ATX inhibitor with an IC50 value of 24.2 nM. ATX inhibitor 18 shows antiproliferative activity and anti-fibrosis activity. ATX inhibitor 18 suppresses collagen deposition in TGF-β-mediated cardiac fibrosis.
For research use only. We do not sell to patients.
- CAS No.: 2402772-30-7
- Formula: C21H17Cl2FN6O
- Molecular Weight:459.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Autotaxin 24.2 nM (IC50) |
ATX inhibitor 18 (compound 8b) (10 µM; 48 h) shows antiproliferative activity in CFs, t-HSC/Cl-6 cells[1].
ATX inhibitor 18 (0-4 µM) shows anti-fibrosis activity with IC50s of 0.87 and 1.10 µM for CFs, t-HSC/Cl-6 cells, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:CFs, t-HSC/Cl-6 cells
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Concentration:10 µM
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Incubation Time:48 h
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Result:Showed antiproliferative activity with inhibitory activity of 81.5% and 79.4% for CFs, t-HSC/Cl-6 cells, respectively.
Chemical Information
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CAS No. 2402772-30-7
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Molecular Weight 459.30
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Formula C21H17Cl2FN6O
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SMILES
O=C(N1CCC2=C(C(NC3=CC=C(C(Cl)=C3)F)=NC=N2)C1)N/N=C/C4=CC=C(C=C4)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ATX inhibitor 18 Related Classifications
HY-146205 Related Classifications
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