Allo-aca
Based on 10 publication(s) in Google Scholar
Allo-aca, a leptin peptidomimetic, is a potent, specific leptin receptor antagonist peptide. Allo-aca blocks leptin signaling and action in numerous in vitro and in vivo models.
For research use only. We do not sell to patients.
- Purity: 99.82%
- CAS No.: 3109368-53-5
- Formula: C48H75N13O15
- Molecular Weight:1074.19
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Allo-aca
More- Cancer Cell. 2026 Mar 9;44(3):658-675.e12. [Abstract]
- Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
- Stem Cell Res Ther. 2025 May 5;16(1):227. [Abstract]
- Int J Mol Sci. 2025 Oct 9;26(19):9819. [Abstract]
- Ann Med. 2024 Dec;56(1):2419990. [Abstract]
- J Endocr Soc. 2025 Dec 24.
- Cancer Res Treat. 2025 Apr;57(2):457-477. [Abstract]
- Andrology. 2025 Feb;13(2):371-381. [Abstract]
- bioRxiv. 2026 Jan 05.
- bioRxiv. 2023 Aug 14.
Customer Validation & Images
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In Vivo Efficacy Study
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In Vivo Efficacy Study
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Histological Imaging/Staining
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Flow Cytometry
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WB
All Neuropeptide Y Receptor Isoforms
More
Biological Activity
Allo-aca inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca inhibits leptin-induced proliferation of MCF-7 cells with an IC50 of 200 pM[1].
Allo-aca at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca inhibits VEGF mitogenic effects. Allo-aca inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3109368-53-5
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Appearance Solid
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Molecular Weight 1074.19
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Formula C48H75N13O15
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Color White to off-white
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Sequence
{H-allo}-Thr-Glu-{Nva}-Val-Ala-Leu-Ser-Arg-{Aca}-NH2
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Sequence Shortening
{H-allo}-TE-{Nva}-VALSR-{Aca}-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (10)
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Journal Impact Factor
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Most Recent
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Cancer Cell
Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases. [Abstract]2026 Mar 9;44(3):658-675.e12. PMID: 41687606
Allo-aca purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2026 Mar 9;44(3):658-675.e12. [Abstract]
KMplots and BLI analysis of the mice received chemotherapy along with Veh. or Allo-aca (1 mg/kg; i.p.; every two days) (n = 8 mice/group).
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Cell Death Dis
Marrow leptin-LEPR signaling rewires mitochondrial oxidative metabolism to confer chemoresistance in acute myeloid leukemia. [Abstract]2026 Feb 23;17(1):249. PMID: 41730833
Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Kaplan-Meier survival curve of MLL-AF9 AML mice (n = 5 mice per group).
Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Representative H&E-stained sections of BM, spleen and liver (scale bars: 20 μm). The results showed that leptin (Allo-aca) (1 mg/kg; i.p.; once daily from days 11 to 20) dampened Ara-C cytotoxicity, extensive leukemic infiltration of liver and spleen.
Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Representative FCM profiles (left) and quantification of YFP+ AML cells in BM, spleen, and liver of MLL-AF9 AML mice (n = 5 mice per group).
Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Western blot analysis of LEPR expression in AML cells under indicated treatments (Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20), ect.). β-actin served as the loading control.
Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Effect of Allo-aca on AML cell chemosensitivity by CCK-8 assay. The inhibition rates were calculated from eight treatment arms: (i) PBS; (ii) Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20) alone; (iii) Leptin alone; (iv) Allo-aca + Leptin; (v) Ara-C alone (or DNR); (vi) Allo-aca + Ara-C (or DNR); (vii) Leptin + Ara-C (or DNR) and (viii) Allo-aca + Leptin + Ara-C (or DNR).
Allo-aca purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2026 Feb 23;17(1):249. [Abstract]
Allo-aca (1 mg/kg; i.p.; once daily from days 11 to 20). Mitochondrial respiration analysis of sorted MLL-AF9 AML cells using Seahorse XF technology (n = 5 mice per group).
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Stem Cell Res Ther
Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression. [Abstract]2025 May 5;16(1):227. PMID: 40325465 -
Int J Mol Sci
Cinnamaldehyde Inhibits Leptin-Induced MMP-1 by Modulating Leptin Receptor/STAT3 and Blocking RhoA/NF-κB Pathways in Human Intervertebral Disc Stem Cells. [Abstract]2025 Oct 9;26(19):9819. PMID: 41097084 -
Ann Med
Human adipose-derived stem cells promote migration of papillary thyroid cancer cell via leptin pathway. [Abstract]2024 Dec;56(1):2419990. PMID: 39450935 -
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Cancer Res Treat
Synergistic Activation of LEPR and ADRB2 Induced by Leptin Enhances ROS Generation in TNBC Cells. [Abstract]2025 Apr;57(2):457-477. PMID: 39164083 -
Andrology
Cellular mechanism underlying leptin-induced anion secretion of rat epididymal epithelial cells. [Abstract]2025 Feb;13(2):371-381. PMID: 38778669 -
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Solvent & Solubility
DMSO : 50 mg/mL (46.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 50 mg/mL (46.55 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Otvos L Jr, et al. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer. Eur J Cancer. 2011;47(10):1578-1584. [Content Brief]
[2]. Coroniti R, et al. Designer Leptin Receptor Antagonist Allo-aca Inhibits VEGF Effects in Ophthalmic Neoangiogenesis Models [published correction appears in Front Mol Biosci. 2016 Nov 18;3:75]. Front Mol Biosci. 2016;3:67. Published 2016 Oct 13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 0.9309 mL | 4.6547 mL | 9.3093 mL | 23.2734 mL |
| 5 mM | 0.1862 mL | 0.9309 mL | 1.8619 mL | 4.6547 mL | |
| 10 mM | 0.0931 mL | 0.4655 mL | 0.9309 mL | 2.3273 mL | |
| 15 mM | 0.0621 mL | 0.3103 mL | 0.6206 mL | 1.5516 mL | |
| 20 mM | 0.0465 mL | 0.2327 mL | 0.4655 mL | 1.1637 mL | |
| 25 mM | 0.0372 mL | 0.1862 mL | 0.3724 mL | 0.9309 mL | |
| 30 mM | 0.0310 mL | 0.1552 mL | 0.3103 mL | 0.7758 mL | |
| 40 mM | 0.0233 mL | 0.1164 mL | 0.2327 mL | 0.5818 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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