Rubranol

ADC Targets in Oncology

2026-04-10

Cell Line	Type	Value	Description	References
RAW264.7	IC₅₀	10.2 μM Compound: 57	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis	[PMID: 33422907]
RAW264.7	IC₅₀	20 μM Compound: 57	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 0.5 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 0.5 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis	[PMID: 33422907]
RAW264.7	IC₅₀	28.4 μg/mL Compound: 57	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 24 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 24 hrs by Griess assay	[PMID: 33422907]
RAW264.7	IC₅₀	45.3 μg/mL Compound: 57	Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis	[PMID: 33422907]
RAW264.7	IC₅₀	5.2 μM Compound: 57	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess method Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess method	[PMID: 33422907]

Cell Line

Type

Value

Description

References

RAW264.7

IC₅₀

10.2 μM

Compound: 57

Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis

[PMID: 33422907]

RAW264.7

IC₅₀

20 μM

Compound: 57

Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production preincubated for 0.5 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based analysis

[PMID: 33422907]

RAW264.7

IC₅₀

28.4 μg/mL

Compound: 57

Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced NO production incubated for 24 hrs by Griess assay

[PMID: 33422907]

RAW264.7

IC₅₀

45.3 μg/mL

Compound: 57

Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of IFN-gamma and LPS-induced COX2 production preincubated for 2 hrs followed by IFN-gamma and LPS stimulation and measured after 16 hrs by spectrophotometric analysis

[PMID: 33422907]

RAW264.7

IC₅₀

5.2 μM

Compound: 57

Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production incubated for 20 hrs by Griess method

[PMID: 33422907]

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