Schinifoline
Based on 1 Customer Validation
Schinifoline is a 4-quinolinone found in Zanthoxylum schinifolium. Schinifoline can inhibit cancer cells proliferation, cause G2/M phase arrest and induce apoptosis. Schinifoline can improve radiosensitizing effect of cancer cells. Schinifoline shows anti-fungal activity. Schinifoline can be used for the researches of cancer and infection, such as lung cancer and C. albicans infection.
For research use only. We do not sell to patients.
- Purity: 99.55%
- CAS No.: 80554-58-1
- Formula: C17H23NO
- Molecular Weight:257.37
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Schinifoline (0-200 μg/mL, 6-24 h) inhibit proliferation in A549 cells[1].
Schinifoline (4 μg/mL, 14 days) inhibits colony forming in A549 cells[1].
Schinifoline (4 μg/mL) induces apoptosis in A549 cells[1].
Schinifoline (4 μg/mL, 12 h) induces G2/M phase arrest in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:4 μg/mL
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Incubation Time:12 h
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Result:Increased cells in G2/M phase.
Decreased cells in S phase.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C. elegans infected with C. albicans[2]
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Dosage:100 mg/L
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Administration:24 h
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Result:Inhibited C. albicans virulence.
Extended the mean lifespan by 75%.
Upregulated vit-1, vit-3, and vit-4 gene expression.
Chemical Information
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CAS No. 80554-58-1
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Appearance Solid
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Molecular Weight 257.37
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Formula C17H23NO
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Color White to off-white
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SMILES
O=C1C=C(CCCCCCC)N(C)C2=C1C=CC=C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (388.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.71 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang CF, et al. Radiosensitizing effect of schinifoline from Zanthoxylum schinifolium Sieb et Zucc on human non-small cell lung cancer A549 cells: a preliminary in vitro investigation. Molecules. 2014 Dec 1;19(12):20128-38. [Content Brief]
[2]. Lu L, et al. Whole transcriptome analysis of schinifoline treatment in Caenorhabditis elegans infected with Candida albicans. Mol Immunol. 2021 Jul;135:312-319. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8855 mL | 19.4273 mL | 38.8546 mL | 97.1364 mL |
| 5 mM | 0.7771 mL | 3.8855 mL | 7.7709 mL | 19.4273 mL | |
| 10 mM | 0.3885 mL | 1.9427 mL | 3.8855 mL | 9.7136 mL | |
| 15 mM | 0.2590 mL | 1.2952 mL | 2.5903 mL | 6.4758 mL | |
| 20 mM | 0.1943 mL | 0.9714 mL | 1.9427 mL | 4.8568 mL | |
| 25 mM | 0.1554 mL | 0.7771 mL | 1.5542 mL | 3.8855 mL | |
| 30 mM | 0.1295 mL | 0.6476 mL | 1.2952 mL | 3.2379 mL | |
| 40 mM | 0.0971 mL | 0.4857 mL | 0.9714 mL | 2.4284 mL | |
| 50 mM | 0.0777 mL | 0.3885 mL | 0.7771 mL | 1.9427 mL | |
| 60 mM | 0.0648 mL | 0.3238 mL | 0.6476 mL | 1.6189 mL | |
| 80 mM | 0.0486 mL | 0.2428 mL | 0.4857 mL | 1.2142 mL | |
| 100 mM | 0.0389 mL | 0.1943 mL | 0.3885 mL | 0.9714 mL |
Schinifoline Related Classifications
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