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Cat. No.: HY-184875

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B-Raf-IN-21

B-Raf-IN-21 is a B-Raf kinase inhibitor with a K_d of 4.8 nM and an IC₅₀ of 6 nM. B-Raf-IN-21 can be used for the research of stroke.

For research use only. We do not sell to patients.

CAS No.: 342434-07-5
Formula: C₁₈H₁₉ClN₄O
Molecular Weight:342.83

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

B-Raf-IN-21 Chemical Structure

CAS No.: 342434-07-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

B-Raf-IN-21 is a B-Raf kinase inhibitor with a K_d of 4.8 nM and an IC₅₀ of 6 nM. B-Raf-IN-21 can be used for the research of stroke^[1].

IC₅₀ & Target

^[1]

B-Raf

4.8 nM (Kd)

B-Raf

6 nM (IC₅₀)

All Raf Isoforms :

In Vitro

B-Raf-IN-21 (compound 8) potently inhibits B-Raf kinase with an IC₅₀ of 6 nM in a cell-free kinase activity assay^[1].
B-Raf-IN-21 binds to B-Raf with a K_d of 4.8 nM in a cell-free fluorescent polarization ligand binding assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 342434-07-5
Molecular Weight 342.83
Formula C₁₈H₁₉ClN₄O
SMILES

ClC=1C=CC(=CC1O)C=2NC(=NC2C=3C=CN=CC3)C(C)(C)CN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Takle AK, et al. The identification of potent and selective imidazole-based inhibitors of B-Raf kinase. Bioorganic & medicinal chemistry letters. 2006 Jan 15;16(2):378-81. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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