B-Raf IN 5
B-Raf IN 5 (compound 3b) is a potent inhibitor of protein kinase B-Raf with an IC50 of 2.0 nM. B-Raf IN 5 is devoid of binding to the secondary target PXR and resists rapid metabolism. B-Raf IN 6 has the potential for the research of cancer disease.
For research use only. We do not sell to patients.
- CAS No.: 2648698-30-8
- Formula: C23H18ClF3N6O3S2
- Molecular Weight:583.01
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
2.06 nM
Compound: 3b
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Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 5 days by MTT assay
Antiproliferative activity against human A-375 cells assessed as inhibition of cell growth measured after 5 days by MTT assay
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[PMID: 34958586] |
Chemical Information
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CAS No. 2648698-30-8
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Molecular Weight 583.01
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Formula C23H18ClF3N6O3S2
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SMILES
O=S(C1=CC(F)=CC=C1F)(NC2=CC(Cl)=CC(C3=C(C4=NC(N)=NC=C4)SC(C5NCCOC5)=N3)=C2F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
B-Raf IN 5 Related Classifications
HY-142820 Related Classifications
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