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Dimethyl fumarate

64 Cited Publications
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Based on 64 publication(s) in Google Scholar

Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research.

For research use only. We do not sell to patients.

  • Purity: 99.95%
  • CAS No.: 624-49-7
  • Formula: C6H8O4
  • Molecular Weight:144.13
  • Storage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Dimethyl fumarate Chemical Structure
    Dimethyl fumarate Chemical Structure
  • Experimental Validation Results for Dimethyl fumarate
  • Experimental Validation Results for Dimethyl fumarate
  • Experimental Validation Results for Dimethyl fumarate
  • Experimental Validation Results for Dimethyl fumarate
  • Experimental Validation Results for Dimethyl fumarate
CAS No.: 624-49-7
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  • Dimethyl fumarate Chemical Structure
    Dimethyl fumarate Chemical Structure
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    Dimethyl fumarate purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1660-1672. [Abstract]

    Customer Validation
     Wild-type (WT) and Gsdmd−/− mice were intraperitoneally injected with 15 mg/kg (body weight) LPS and treated with normal saline, SK56 (1 mg/kg (body weight) i.v.) or 50 mg/kg (body weight) DSF, 50 mg/kg (body weight) DMF or 20 mg/kg (body weight) Necrosulfonamide (NSA) i.p. at 16 h after LPS injection. Blood AST, BUN, ALT and CK levels in wild-type and Gsdmd−/− mice treated as in a at day 2 after LPS injection; n = 6 mice.

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    Dimethyl fumarate purchased from MedChemExpress. Usage Cited in: Nature. 2023 Mar;615(7952):490-498. [Abstract]

    Customer Validation
     Both Fumarate hydratase-IN-1 (FHIN1) and Dimethyl fumarate (DMF) treatment limit IFNβ-induced STAT1 and JAK1 phosphorylation in BMDMs.

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    Dimethyl fumarate purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2023 Mar:189:106697. [Abstract]

    Customer Validation
     The oligomerized MLKL induced by TSI in both J774A.1 (Fig. E) and BMDMs (Fig. F) are almost completely inhibited by Dimethyl fumarate (DMF; 25, 50 μM; 3 h) treatment in these murine macrophages.

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    Dimethyl fumarate purchased from MedChemExpress. Usage Cited in: J Mol Endocrinol. 2018 Oct 15;61(4):163-172. [Abstract]

    Customer Validation
     Keratinocytes are subjected to normal glucose (NG), H2O2, or high glucose (HG) in the presence or absence of DMF, to measure the levels of NRF2 protein.

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    Dimethyl fumarate purchased from MedChemExpress. Usage Cited in: Aging (Albany NY). 2018 Aug 16;10(8):2016-2036. [Abstract]

    Customer Validation
     Relative changes in the expression of Nrf2, pNrf2 and HO-1 after treatment with D-gal alone or combined with DMF or lycopene.

  • Dimethyl fumarate