Cat. No.: HY-N0457

Chicoric acid

(Synonyms: Cichoric acid; Dicaffeoyltartaric acid)

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

Chicoric acid (Cichoric acid), an orally active dicaffeyltartaric acid, induces reactive oxygen species (ROS) generation. Chicoric acid inhibits cell viability and induces mitochondria-dependent apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. Chicoric acid increases glucose uptake, improves insulin resistance, and attenuates glucosamine-induced inflammation. Chicoric acid has antidiabetic properties and antioxidant, anti-inflammatory effects.

For research use only. We do not sell to patients.

Purity: 99.86%
CAS No.: 6537-80-0
Formula: C₂₂H₁₈O₁₂
Molecular Weight:474.37

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Chicoric acid Chemical Structure

CAS No.: 6537-80-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	IC₅₀	20.1 μM Compound: 3 (-)-L-chichoric acid	Compound was evaluated for the cytoprotection of CEM-SS cells by XTT cytoprotection assay through the NCI AIDS Screen Compound was evaluated for the cytoprotection of CEM-SS cells by XTT cytoprotection assay through the NCI AIDS Screen	[PMID: 10212126]
MT2	EC₅₀	0.81 μM Compound: L-CA	Antiviral activity against HIV LAI infected in human MT2 cells assessed as protection against virus-induced cytopathic effect Antiviral activity against HIV LAI infected in human MT2 cells assessed as protection against virus-induced cytopathic effect	[PMID: 20977258]
MT4	CC₅₀	115 μM Compound: L-CA	Cytotoxicity against human MT4 cells by MTT assay Cytotoxicity against human MT4 cells by MTT assay	[PMID: 18243421]
MT4	CC₅₀	115 μM Compound: L-chicoric acid	Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 20541944]
MT4	EC₅₀	12.7 μM Compound: L-CA	Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay Antiviral activity against HIV1 3B infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay	[PMID: 18243421]
MT4	EC₅₀	12.7 μM Compound: L-chicoric acid	Cytotoxicity gainst human MT4 cells after 3 days by MTT assay Cytotoxicity gainst human MT4 cells after 3 days by MTT assay	[PMID: 20541944]
MT4	EC₅₀	21.2 μM Compound: 3 (-)-L-chichoric acid	Concentration of compound required to protect 50% of cells against retroviral cytopathic effects in HIV-2 (ROD) Concentration of compound required to protect 50% of cells against retroviral cytopathic effects in HIV-2 (ROD)	[PMID: 10212126]
MT4	EC₅₀	5.3 μM Compound: 3 (-)-L-chichoric acid	Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-1 (IIIa) Concentration of compound required to protect 50% of MT-4 cells against retroviral cytopathic effects by HIV-1 (IIIa)	[PMID: 10212126]
MT4	IC₅₀	45 μM Compound: 3 (-)-L-chichoric acid	Concentration of compound required to reduce MT-4 cell viability by 50% Concentration of compound required to reduce MT-4 cell viability by 50%	[PMID: 10212126]

In Vitro

Chicoric acid (Cichoric acid; 10-200 μM; for 24, 48, and 72 h) causes a dose- and time-dependent decrease in cell viability^[1].
Chicoric acid (100 μM; 48 h) induces apoptosis through caspase-3-dependent pathway^[1].
Chicoric acid (100 μM; 48 h) decreases the protein level of p-Akt^[1].
Chicoric acid (25, 50, 100 μM; for 24 hours) dramatically improves glucose uptake in a dose-dependent manner, and Chicoric acid further enhances insulin-induced (100 nM; 30 min) glucose uptake by 57.7% in HepG2 cells^[2].
Chicoric acid (100 μM; for 24 hours) restores glucosamine-induced impairment of GLUT2 translocation through activating PI3K/Akt pathway in HepG2 cells^[2].
Chicoric acid (100 μM) has no effects on HepG2 cell viability^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

3T3-L1 preadipocytes
Concentration:

10-200 μM
Incubation Time:

24, 48, and 72 hours
Result:

Had no effect on the viability of 3T3-L1 preadipocytes with 10-50 μM for 24 h, but significantly decreased cell viability with 100 μM and 200 μM.

Apoptosis Analysis^[1]

Cell Line:

3T3-L1 preadipocytes
Concentration:

100 μM
Incubation Time:

48 hours
Result:

Demonstrated typical characteristics of apoptosis such as cell shrinkage, chromatin condensation, and the increased permeability of cell membranes after DAPI and AO/EB staining.

Western Blot Analysis^[1]

Cell Line:

3T3-L1 preadipocytes
Concentration:

100 μM
Incubation Time:

48 hours
Result:

Decreased the protein level of p-Akt in a dose- and time-dependent manner.
The protein level of total Akt was not affected

In Vivo

Chicoric acid (Cichoric acid; 60 mg/kg/day; drinking water for 4 weeks) inhibits pancreas apoptosis and adjusts islet function in diabetic mice, leading to an increase in insulin generation and secretion in C57BL/6J mice with Streptozotocin (STZ; 50 mg/kg; ip; for consecutive 5 days)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J mice with STZ (50 mg/kg; ip; for consecutive 5 days)^[3]
Dosage:

60 mg/kg
Administration:

Drinking water; daily; for 4 weeks
Result:

Inhibited pancreas apoptosis and adjusted islet function in diabetic mice, leading to an increase in insulin generation and secretion.
Regulated mitochondrial biogenesis, glycogen synthesis, and inhibited inflammation via activating antioxidant responses.
Showed a remarkable increase in body weight starting at week 7.

Chemical Information

CAS No. 6537-80-0
Appearance Solid
Molecular Weight 474.37
Formula C₂₂H₁₈O₁₂
Color White to yellow
SMILES

O=C(O)[C@H](OC(/C=C/C1=CC=C(O)C(O)=C1)=O)[C@@H](OC(/C=C/C2=CC=C(O)C(O)=C2)=O)C(O)=O
Synonyms

Cichoric acid; Dicaffeoyltartaric acid
Structure Classification
- Phenylpropanoids
- Other Phenylpropanoids
- Phenols
- Polyphenols
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

All Bio/Physico-chemical Assay

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Journal Impact Factor

Phytomedicine

Cichoric acid-loaded hydroxyapatite nanorods remodel the immune microenvironment to enhance bone regeneration. [Abstract]

2026 Jan:150:157701. PMID: 41421279
Antioxidants (Basel)

Bioactive Extracts and Constituents from Taraxacum mongolicum: Antioxidant, Anti-Inflammatory, Enzyme-Inhibitory, and Molecular Docking Studies. [Abstract]

2026 May 29;15(6):688. PMID: 42351994

Chicoric acid purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2026 May 29;15(6):688. [Abstract]

Antioxidant activities of T. mongolicum isolated components.

Chicoric acid purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2026 May 29;15(6):688. [Abstract]

Enzyme suppression activities of Taraxacum mongolicum isolated components.

Chicoric acid purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2026 May 29;15(6):688. [Abstract]

NO inhibitory activities of Taraxacum mongolicum isolated components.
Foods

Design of a Plant-Based Smoothie: Exploiting Ingredient Complementarity for a Diversified (Poly)phenolic Profile Quantified by Targeted LC-MS/MS Analysis. [Abstract]

2026 Apr 9;15(8):1293. PMID: 42073181
SSRN

2024 Mar 21.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (210.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (210.81 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.1081 mL

10.5403 mL

21.0806 mL

5 mM

0.4216 mL

2.1081 mL

4.2161 mL

10 mM

0.2108 mL

1.0540 mL

2.1081 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Haifang Xiao, et al. Chicoric acid induces apoptosis in 3T3-L1 preadipocytes through ROS-mediated PI3K/Akt and MAPK signaling pathways. J Agric Food Chem. 2013 Feb 20;61(7):1509-20. [Content Brief]

[2]. Di Zhu, et al. Cichoric Acid Reverses Insulin Resistance and Suppresses Inflammatory Responses in the Glucosamine-Induced HepG2 Cells. J Agric Food Chem. 2015 Dec 30;63(51):10903-13. [Content Brief]

[3]. Di Zhu, et al. Cichoric acid improved hyperglycaemia and restored muscle injury via activating antioxidant response in MLD-STZ-induced diabetic mice. Food Chem Toxicol. 2017 Sep;107(Pt A):138-149. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	2.1081 mL	10.5403 mL	21.0806 mL	52.7015 mL
	5 mM	0.4216 mL	2.1081 mL	4.2161 mL	10.5403 mL
	10 mM	0.2108 mL	1.0540 mL	2.1081 mL	5.2701 mL
	15 mM	0.1405 mL	0.7027 mL	1.4054 mL	3.5134 mL
	20 mM	0.1054 mL	0.5270 mL	1.0540 mL	2.6351 mL
	25 mM	0.0843 mL	0.4216 mL	0.8432 mL	2.1081 mL
	30 mM	0.0703 mL	0.3513 mL	0.7027 mL	1.7567 mL
	40 mM	0.0527 mL	0.2635 mL	0.5270 mL	1.3175 mL
	50 mM	0.0422 mL	0.2108 mL	0.4216 mL	1.0540 mL
	60 mM	0.0351 mL	0.1757 mL	0.3513 mL	0.8784 mL
	80 mM	0.0264 mL	0.1318 mL	0.2635 mL	0.6588 mL
	100 mM	0.0211 mL	0.1054 mL	0.2108 mL	0.5270 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Chicoric acid

4 Cited Publications

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Chicoric acid

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Publications Citing Use of MedChemExpress (MCE) Chicoric acid

Biological Activity

Chemical Information

Publications (4)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Chicoric acid Related Classifications

HY-N0457 Related Classifications