Dextromilnacipran
Based on 1 Customer Validation
Dextromilnacipran ((1R,2S)-Milnacipran; F2696) is an orally active Serotonin (HY-B1473A)/Noradrenaline (HY-13715) transporter inhibitor. Dextromilnacipran inhibits Serotonin and Noradrenaline reuptake. Dextromilnacipran can be used for the research of depression, fibromyalgia.
For research use only. We do not sell to patients.
- Purity: 99.90%
- CAS No.: 96847-55-1
- Formula: C15H22N2O
- Molecular Weight:246.35
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 3.4 μM (alpha-adrenergic receptor)
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Cell Line
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Type | Value | Description | References |
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| CHO | IC50 |
64 nM
Compound: rel-Milnacipran
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Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serotonin addition measured after 20 mins by liquid scintillation counting method
Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serotonin addition measured after 20 mins by liquid scintillation counting method
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[PMID: 27865645] |
Chemical Information
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CAS No. 96847-55-1
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Appearance Liquid (Density: 1.077±0.06 g/cm3)
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Molecular Weight 246.35
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Formula C15H22N2O
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Color Colorless to light yellow
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SMILES
O=C([C@@]1(C2=CC=CC=C2)[C@@H](CN)C1)N(CC)CC
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Synonyms
(1R,2S)-Milnacipran; F2696
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (202.96 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 4.0593 mL | 20.2963 mL | 40.5927 mL | 101.4816 mL |
| 5 mM | 0.8119 mL | 4.0593 mL | 8.1185 mL | 20.2963 mL | |
| 10 mM | 0.4059 mL | 2.0296 mL | 4.0593 mL | 10.1482 mL | |
| 15 mM | 0.2706 mL | 1.3531 mL | 2.7062 mL | 6.7654 mL | |
| 20 mM | 0.2030 mL | 1.0148 mL | 2.0296 mL | 5.0741 mL | |
| 25 mM | 0.1624 mL | 0.8119 mL | 1.6237 mL | 4.0593 mL | |
| 30 mM | 0.1353 mL | 0.6765 mL | 1.3531 mL | 3.3827 mL | |
| 40 mM | 0.1015 mL | 0.5074 mL | 1.0148 mL | 2.5370 mL | |
| 50 mM | 0.0812 mL | 0.4059 mL | 0.8119 mL | 2.0296 mL | |
| 60 mM | 0.0677 mL | 0.3383 mL | 0.6765 mL | 1.6914 mL | |
| 80 mM | 0.0507 mL | 0.2537 mL | 0.5074 mL | 1.2685 mL | |
| 100 mM | 0.0406 mL | 0.2030 mL | 0.4059 mL | 1.0148 mL |
Dextromilnacipran Related Classifications
HY-14794 Related Classifications
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