E822-1968
E822-1968 is an UT-A2 inhibitor with a human IC50 of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.
For research use only. We do not sell to patients.
- CAS No.: 1037259-63-4
- Formula: C19H19N3O3
- Molecular Weight:337.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
E822-1968 potently inhibits UT-A2-mediated urea transport in UT-A2-overexpressing HEK293F cells with an IC50 of 0.44 μM[1].
E822-1968 weakly inhibits UT-A3-mediated urea transport in UT-A3-overexpressing HEK293F cells with an IC50 of 3.42 μM[1].
E822-1968 (10 nM-100 μM; 50 seconds) does not inhibit UT-B-mediated urea transport in UT-B-overexpressing HEK293F cells[1].
E822-1968 (1-10 μM; 30 minutes) does not inhibit rat UT-A1-mediated urea transport in stably expressing MDCK cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1037259-63-4
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Molecular Weight 337.37
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Formula C19H19N3O3
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SMILES
COC1=CC(CNC(C2=CC(C3=CC=CC(OC)=C3)=NN2)=O)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E822-1968 Related Classifications
HY-183637 Related Classifications
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