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MED29 - mediator complex subunit 29 Gene

Also Known as IXL; MED2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55588

About MED29

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:39,391,378-39,400,641 (from NCBI)

This gene has 6 transcripts (splice variants) and 88 orthologues. Ubiquitous expression in brain (RPKM 2.7), thyroid (RPKM 2.6) and 25 other tissues.

Summary

MED29 is a subunit of the Mediator complex, a multiprotein coactivator of RNA transcription that interacts with DNA-bound transcriptional activators, RNA polymerase II (see MIM 180660), and general initiation factors (Sato et al., 2003 [PubMed 14576168]).[supplied by OMIM, Aug 2009]

MED29 Products (2)

mRNA	Protein	Name
NM_001317770.3	NP_001304699.2	mediator of RNA polymerase II transcription subunit 29 isoform 2
NM_017592.4	NP_060062.2	mediator of RNA polymerase II transcription subunit 29 isoform 1

MED29 Protein Structure

Med29

0
100
200 a.a.

Protein Preferred Names	Protein Names
mediator of RNA polymerase II transcription subunit 29	intersex-like protein

MED29 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MED29	Q9NX70	SSC5D	Homo sapiens	A1L4H1	Y2H Prey Pooling	32296183
Intra	MED29	Q9NX70	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Cross	MED29	Q9NX70	Med30	Mus musculus	Q9CQI9	Anti Tag CoIP	24882805
Intra	MED29	Q9NX70	MED19	Homo sapiens	A0JLT2	Anti Tag CoIP	33961781
Intra	MED29	Q9NX70	MED19	Homo sapiens	A0JLT2	Anti Tag CoIP	15175163
Intra	MED29	Q9NX70	MED19	Homo sapiens	A0JLT2	Anti Tag CoIP	14638676
Intra	MED29	Q9NX70	MED6	Homo sapiens	O75586	Anti Tag CoIP	14576168
Intra	MED29	Q9NX70	MED6	Homo sapiens	O75586	Anti Tag CoIP	35271311
Intra	MED29	Q9NX70	MED6	Homo sapiens	O75586	Anti Tag CoIP	15175163
Intra	MED29	Q9NX70	MED6	Homo sapiens	O75586	Anti Tag CoIP	33961781
Intra	MED29	Q9NX70	MED6	Homo sapiens	O75586	Anti Tag CoIP	24882805
Intra	MED29	Q9NX70	MED18	Homo sapiens	Q9BUE0	Anti Tag CoIP	24882805
Intra	MED29	Q9NX70	MED18	Homo sapiens	Q9BUE0	Anti Tag CoIP	33961781
Intra	MED29	Q9NX70	MED18	Homo sapiens	Q9BUE0	Anti Tag CoIP	14576168
Intra	MED29	Q9NX70	MED18	Homo sapiens	Q9BUE0	Anti Tag CoIP	35271311
Intra	MED29	Q9NX70	MED18	Homo sapiens	Q9BUE0	Anti Tag CoIP	14638676
Intra	MED29	Q9NX70	MED18	Homo sapiens	Q9BUE0	Anti Tag CoIP	15175163
Intra	MED29	Q9NX70	MED20	Homo sapiens	Q9H944	Anti Tag CoIP	35271311
Intra	MED29	Q9NX70	MED20	Homo sapiens	Q9H944	Anti Tag CoIP	14576168
Intra	MED29	Q9NX70	MED20	Homo sapiens	Q9H944	Anti Tag CoIP	33961781
Intra	MED29	Q9NX70	MED20	Homo sapiens	Q9H944	Chromatography	14576168
Intra	MED29	Q9NX70	MED20	Homo sapiens	Q9H944	Anti Tag CoIP	15175163
Intra	MED29	Q9NX70	MED22	Homo sapiens	Q15528	Anti Tag CoIP	33961781
Intra	MED29	Q9NX70	MED22	Homo sapiens	Q15528	Anti Tag CoIP	15175163
Intra	MED29	Q9NX70	MED22	Homo sapiens	Q15528	Anti Tag CoIP	14638676
Intra	MED29	Q9NX70	MED22	Homo sapiens	Q15528	Anti Tag CoIP	35271311
Intra	MED29	Q9NX70	MED28	Homo sapiens	Q9H204	Anti Tag CoIP	33961781
Intra	MED29	Q9NX70	MED28	Homo sapiens	Q9H204	Anti Tag CoIP	15175163
Intra	MED29	Q9NX70	MED28	Homo sapiens	Q9H204	Anti Tag CoIP	35271311
Cross	MED29	Q9NX70	Med11	Mus musculus	Q9D8C6	Anti Tag CoIP	24882805
Intra	MED29	Q9NX70	ABI3	Homo sapiens	Q9P2A4	Validated Y2H	32296183
Cross	MED29	Q9NX70	Med8	Mus musculus	Q9D7W5	Anti Tag CoIP	24882805

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fleck Retina, Familial Benign	FRFB Familial Benign Flecked Retina Familial Benign Fleck Retina
Fetishism	Fetishism, Psychiatric
Bubonic Plague	Black Death Plague, Bubonic Plague, Septicemic Pestis Bubonica

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08300	MED29 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MED29	MGD	MGI:1914474
Canis familiaris	MED29	VGNC	VGNC:43136
Rattus norvegicus	MED29	RGD	RGD:1311009
Macaca mulatta	MED29	VGNC	VGNC:74557
Bos taurus	MED29	VGNC	VGNC:31365
Others	MED29	NCBI