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Cat. No.: HY-106706

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Picumast

Name: Picumast
Brand: MedChemExpress
SKU: HY-106706
Availability: PreOrder

(Synonyms: Auteral; BM 15100)

Picumast (Auteral; BM 15100) is an orally active antiallergic agent with histamine receptor antagonistic activity. Picumast inhibits allergy-related cascade reactions by suppressing mediator release from tissue mast cells while exerting histamine antagonistic effects. Picumast inhibits allergic reactions in rats, guinea pigs, and cynomolgus monkeys. Picumast can be used in allergy-related research.

For research use only. We do not sell to patients.

CAS No.: 39577-20-3
Formula: C₂₅H₃₁Cl₃N₂O₃
Molecular Weight:513.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Picumast Chemical Structure

CAS No.: 39577-20-3

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
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Biological Activity

Description

All Histamine Receptor Isoforms :

In Vitro

Picumast (BM 15100) dose-dependently inhibits labelled histamine uptake by isolated human leucocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Picumast (BM 15100) (0.75 mg/kg; intravenous injection) significantly inhibits passive cutaneous anaphylaxis (PCA) reactions in rats, while also suppressing degranulation of mesenteric mast cells and histamine-induced cutaneous reactions in rats^[1].
Picumast (0.1‑0.8 mg/kg; p.o.) inhibits active cutaneous anaphylaxis (ACA) reactions in cynomolgus monkeys, with a significant inhibitory effect observed at the dose of 0.1 mg/kg^[1].
Picumast (0.75 mg/kg; p.o.) inhibits allergic conjunctivitis and hyperemia symptoms in guinea pigs^[1].
Picumast (0.4 mg/kg; p.o.) inhibits allergic bronchospasm in guinea pigs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 39577-20-3
Molecular Weight 513.88
Formula C₂₅H₃₁Cl₃N₂O₃
SMILES

O=C1OC2=C(C(C)=C1C)C=CC(OCCCN3CCN(CC3)CC4=CC=C(C=C4)Cl)=C2.Cl.Cl
Synonyms

Auteral; BM 15100
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Roesch A. Anti-allergic properties of a new coumarin compound (BM 15,100) [proceedings]. Br J Pharmacol. 1976 Jul;57(3):438P.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Picumast

All Histamine Receptor Isoforms