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Cat. No.: HY-177432

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TMX-4140

TMX-4140 is a selective PIP4K2C ligand with a K_d of 7.2 nM. TMX-4140 can be used to synthesize the PROTAC degrader TMX-4153 (HY-153119).

For research use only. We do not sell to patients.

CAS No.: 2867519-51-3
Formula: C₂₅H₂₀ClN₅O
Molecular Weight:441.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TMX-4140 Chemical Structure

CAS No.: 2867519-51-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

TMX-4140 is a selective PIP4K2C ligand with a K_d of 7.2 nM. TMX-4140 can be used to synthesize the PROTAC degrader TMX-4153 (HY-153119)^[1].

IC₅₀ & Target

^[1]

PIP4K2C

7.2 nM (Kd)

All PI5P4K Isoforms :

PI5P4Kγ

In Vitro

TMX-4140 binds PIP4K2C with K_D = 7.2 nM while sparing PIP4K2B (K_D >10000 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2867519-51-3
Molecular Weight 441.91
Formula C₂₅H₂₀ClN₅O
SMILES

ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N5CCCC5=O)=CN=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angewandte Chemie (International ed. in English). 2023 Apr 24;62(18):e202302364. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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TMX-4140

All PI5P4K Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TMX-4140 Related Classifications

HY-177432 Related Classifications

Bioz

Keywords

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