WF-536
WF-536 is an orally active inhibitor of Rho-associated coiled-coil-containing protein kinase (ROCK). WF-536 has tumor anti-metastatic activity. WF-536 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 539857-64-2
- Formula: C14H16ClN3O
- Molecular Weight:277.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
WF-536 (1, 3, 10, 30, 100 μM) inhibits both invasion and migration by LLC cells and invasion, migration, and formation of capillarylike tubes on Matrigel by endothelial cells, without cytotoxicity or anti-proliferative action in either cell type[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LLC cells, Human umbilical vein endothelial cells
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Concentration:1, 3, 10, 30 μM
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Incubation Time:6 h (tumor cells), 4 h (endothelial cells)
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Result:Significantly inhibited LLC-cell migration, with inhibitory rates of 23% and 44% at 10 and 30 μM, respectively.
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Cell Line:LLC cells, Human umbilical vein endothelial cells
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Concentration:1, 3, 10, 30 μM
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Incubation Time:18 h
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Result:Showed significant and concentration-dependent inhibition of LLC-cell invasion.
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Cell Line:LLC cells, Human umbilical vein endothelial cells
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Concentration:1, 30, 100 μM
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Incubation Time:24, 48, 72, and 96 h
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Result:Showed no significant effect at 1-30 μM on the proliferation up to 96 h incubation, although the proliferation was decreased at 100 μM over 48 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 mice (male, 6-week old)[1]
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Dosage:0.3, 1, 3 mg/kg
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Administration:Oral; daily; for 28 days
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Result:Significantly reduced the number of pulmonary metastatic colonies of LLC in a dose-dependent manner (0.3- 3 mg/kg).
Chemical Information
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CAS No. 539857-64-2
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Molecular Weight 277.75
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Formula C14H16ClN3O
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SMILES
O=C(C1=CC=C(C=C1)[C@@H](C)N)NC2=CC=NC=C2.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
WF-536 Related Classifications
HY-118837 Related Classifications
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