4-MeO-MiPT
4-MeO-MiPT is a serotonin transporter (SERT) inhibitor and serotonin 2A receptor (5-HT2A) agonist with pIC50 and IC50 values of 57 nM and 0.43 nM for human SERT, and pEC50 and EC50 values of 23 nM and 2.3 nM for human 5-HT2A, respectively. 4-MeO-MiPT blocks serotonin uptake via SERT, acts as an agonist at 5-HT2A receptors, and exhibits agonist activity at 5-HT1A, 5-HT1D, 5-HT2B, and 5-HT2C receptors. 4-MeO-MiPT can be used for the research of depression.
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- CAS No.: 96096-53-6
- Formule: C15H22N2O
- Masse moléculaire:246.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
5-HT2A Receptor 23 nM (EC50) |
5-HT2A Receptor 2.3 nM (pEC50) |
In Vitro
4-MeO-MiPT displays nanomolar affinity for multiple serotonin receptor subtypes, SERT, alpha2-adrenergic receptors, and sigma-2 receptors[1].
4-MeO-MiPT is a full agonist at human 5-HT2A receptors and a partial agonist at human 5-HT2B and 5-HT2C receptors, with highest potency at human 5-HT2A and 5-HT2B receptors[1].
4-MeO-MiPT potently inhibits serotonin uptake via SERT in rat brain synaptosomes with an IC50 of 57 nM, and has no meaningful activity at DAT or NET[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (male and female, 8 weeks of age)[1]
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Dosage:0.03 mg/kg; 0.1 mg/kg; 0.3 mg/kg; 1 mg/kg; 10 mg/kg; 30 mg/kg
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Administration:s.c.; single dose
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Result:Induced a dose-dependent increase in HTR counts, with an ED50 of 0.97 mg/kg and a maximal efficacy of 39 HTRs per 30 minutes.
Increased HTR counts relative to 30 mg/kg 4-MeO-MiPT alone when preceded by 3 mg/kg WAY100635 (HY-10349) pretreatment.
Chemical Information
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CAS No. 96096-53-6
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Masse moléculaire 246.35
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Formule C15H22N2O
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SMILES
COC1=C2C(CCN(C(C)C)C)=CNC2=CC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocole
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
4-MeO-MiPT Related Classifications
HY-W682464 Related Classifications
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