Cat. No.: HY-114267

Cbz-B3A

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Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).

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Pureté: 98.63%
CAS No.: 1884710-81-9
Formule: C₃₅H₅₈N₆O₉
Masse moléculaire:706.87

Stockage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cbz-B3A Chemical Structure

CAS No.: 1884710-81-9

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that appear to bind to ubiquilins 1, 2, and 4, and Cbz-B3A inhibits the phosphorylation of eIF4E-binding protein 1 (4EBP1).

IC₅₀ & Target

mTORC1 signaling^[1].

Voir tous les produits spécifiques à Isoform mTOR :

In Vitro

Cbz-B3A slows cellular growth of some human leukemia cell lines, but is not cytotoxic.
Cbz-B3A has a larger effect on the phosphorylation of 4EBP1 than p70^S6k compared to repamycin. Cbz-B3A inhibits mTOR through Ubiquilins.
Cbz-B3A decreases the incorporation of [³⁵S]methionine/cysteine into protein in a dose-dependent manner, with maximal inhibition of 68% observed at 10 μM, and an EC₅₀ of ~3 μM.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1884710-81-9
Appearance Solid
Masse moléculaire 706.87
Formule C₃₅H₅₈N₆O₉
Color White to light yellow
SMILES

O=C(OC(C)(C)C)N/C(NC(OC(C)(C)C)=O)=N/CCC[C@H](NC(OC(C)(C)C)=O)C(NCCCCCCNC(OCC1=CC=CC=C1)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 20 mg/mL (28.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.4147 mL

7.0734 mL

14.1469 mL

5 mM

0.2829 mL

1.4147 mL

2.8294 mL

10 mM

0.1415 mL

0.7073 mL

1.4147 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Coffey RT, et al. Ubiquilin-mediated Small Molecule Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling. J Biol Chem. 2016 Mar 4;291(10):5221-33. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.4147 mL	7.0734 mL	14.1469 mL	35.3672 mL
	5 mM	0.2829 mL	1.4147 mL	2.8294 mL	7.0734 mL
	10 mM	0.1415 mL	0.7073 mL	1.4147 mL	3.5367 mL
	15 mM	0.0943 mL	0.4716 mL	0.9431 mL	2.3578 mL
	20 mM	0.0707 mL	0.3537 mL	0.7073 mL	1.7684 mL
	25 mM	0.0566 mL	0.2829 mL	0.5659 mL	1.4147 mL

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Voir tous les produits spécifiques à Isoform mTOR

Activité biologique

Chemical Information

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Cbz-B3A Related Classifications

HY-114267 Related Classifications