L-Serine
Based on 15 publication(s) in Google Scholar
L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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- Pureté: 99.95%
- CAS No.: 56-45-1
- Formule: C3H7NO3
- Masse moléculaire:105.09
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Stockage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Publications Citing Use of MedChemExpress (MCE) L-Serine
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell Host Microbe. 2026 Jun 10;34(6):1000-1017.e5. [Abstract]
- Redox Biol. 2024 May:71:103112. [Abstract]
- Acta Pharm Sin B. 2022 Sep;12(9):3618-3638. [Abstract]
- Biomaterials. 2025 Dec 14:329:123922. [Abstract]
- Food Chem. 2026 Apr 6:12:100401. [Abstract]
- Ecotoxicol Environ Saf. 2024 Nov 1:286:117216. [Abstract]
- Ecotoxicol Environ Saf. 2024 Jul 2:281:116678. [Abstract]
- Molecules. 2025 Mar 9;30(6):1224. [Abstract]
- Naunyn Schmiedebergs Arch Pharmacol. 2025 Dec 18. [Abstract]
- J Diabetes Investig. 2025 May;16(5):775-790. [Abstract]
- Amino Acids. 2024 Sep 18;56(1):56. [Abstract]
- Physiol Rep. 2025 Aug;13(16):e70465. [Abstract]
- bioRxiv. 2025 July 15.
- Research Square Print. 2022 May.
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Activité biologique
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Microbial Metabolite |
Human Endogenous Metabolite |
L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. In cell cultures, L-Serine is a conditionally essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization.L-Serine and the products of its metabolism have been recognized not only to be essential for cell proliferation but also to be necessary for specific functions in the central nervous system[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 56-45-1
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Appearance Solid
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Masse moléculaire 105.09
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Formule C3H7NO3
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Color White to off-white
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SMILES
N[C@@H](CO)C(O)=O
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Synonyms
Serine
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Structure Classification
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Publications (15)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Host Microbe
Microbiota-driven gut-brain signaling underlies antidepressant effects of a GLP-1 analog. [Abstract]2026 Jun 10;34(6):1000-1017.e5. PMID: 42269582 -
Redox Biol
Enteric coronavirus PDCoV evokes a non-Warburg effect by hijacking pyruvic acid as a metabolic hub. [Abstract]2024 May:71:103112. PMID: 38461791 -
Acta Pharm Sin B
Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1 α/NF- κ B feedback pathway to inhibit liver fibrosis. [Abstract]2022 Sep;12(9):3618-3638. PMID: 36176909 -
Biomaterials
Ultrasound-responsive renal-targeted nanoparticles deliver TAK-242 to inhibit NF-κB/NLRP3 signaling and attenuate sepsis-associated acute kidney injury. [Abstract]2025 Dec 14:329:123922. PMID: 41481962 -
Food Chem
Multi-omics reveals molecular basis of beef quality differences between Qinchuan and Nanyang cattle. [Abstract]2026 Apr 6:12:100401. PMID: 42011267 -
Ecotoxicol Environ Saf
The attenuating effects of serine against cadmium induced immunotoxicity through regulating M1/M2 and Th1/Th2 balance in spleen of C57BL/6 mice. [Abstract]2024 Nov 1:286:117216. PMID: 39437518
L-Serine purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 Nov 1:286:117216. [Abstract]
L-serine (50 g/L; drinking water administration). Immunohistochemical staining of CD68 (macrophage marker).
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Ecotoxicol Environ Saf
The role of neutrophil extracellular traps in β-methylamino L-alanine-induced liver injury in mice. [Abstract]2024 Jul 2:281:116678. PMID: 38964067
L-Serine purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 Jul 2:281:116678. [Abstract]
L-serine (300 mg/kg; i.v.). Immunofluorescence staining of Ly6G and citH3 in different groups of liver tissues.
L-Serine purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 Jul 2:281:116678. [Abstract]
L-serine (300 mg/kg; i.v.). Changes of Cleaved-Caspase 3, NETs formation-associated proteins citH3 and MPO, ERK/p38 signaling pathway proteins in different groups.
L-Serine purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 Jul 2:281:116678. [Abstract]
L-serine (300 mg/kg; i.v.). qRT-PCR was applied for determine the expression of TNF-α in different groups.
L-Serine purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2024 Jul 2:281:116678. [Abstract]
L-serine (300 mg/kg; i.v.). DNA content in serum of different groups of mice.
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Molecules
Seeking Correlation Among Porin Permeabilities and Minimum Inhibitory Concentrations Through Machine Learning: A Promising Route to the Essential Molecular Descriptors. [Abstract]2025 Mar 9;30(6):1224. PMID: 40142001 -
Naunyn Schmiedebergs Arch Pharmacol
Andrographolide blocked the progression of endometriosis by promoting ferroptosis via inhibiting anabolism of serine. [Abstract]2025 Dec 18. PMID: 41408483 -
J Diabetes Investig
YY2 mediates transcriptional repression of PHGDH and expedites oxidative stress in retinal pigment epithelial cells in diabetic retinopathy. [Abstract]2025 May;16(5):775-790. PMID: 39992052 -
Amino Acids
Identification of amino acids metabolomic profiling in human plasma distinguishes lupus nephritis from systemic lupus erythematosus. [Abstract]2024 Sep 18;56(1):56. PMID: 39292313 -
Physiol Rep
Metabolic shifts in plasma amino acids and related metabolites in response to SGLT2 inhibition and hyperglycemia in type 1 diabetes. [Abstract]2025 Aug;13(16):e70465. PMID: 40842430 -
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Solvant et solubilité
H2O : 50 mg/mL (475.78 mM; Need ultrasonic)
Methanol : < 1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (951.57 mM); Clear solution; Need ultrasonic
Pureté et documentation
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Fiche technique (271 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 9.5157 mL | 47.5783 mL | 95.1565 mL | 237.8913 mL |
| 5 mM | 1.9031 mL | 9.5157 mL | 19.0313 mL | 47.5783 mL | |
| 10 mM | 0.9516 mL | 4.7578 mL | 9.5157 mL | 23.7891 mL | |
| 15 mM | 0.6344 mL | 3.1719 mL | 6.3438 mL | 15.8594 mL | |
| 20 mM | 0.4758 mL | 2.3789 mL | 4.7578 mL | 11.8946 mL | |
| 25 mM | 0.3806 mL | 1.9031 mL | 3.8063 mL | 9.5157 mL | |
| 30 mM | 0.3172 mL | 1.5859 mL | 3.1719 mL | 7.9297 mL | |
| 40 mM | 0.2379 mL | 1.1895 mL | 2.3789 mL | 5.9473 mL | |
| 50 mM | 0.1903 mL | 0.9516 mL | 1.9031 mL | 4.7578 mL | |
| 60 mM | 0.1586 mL | 0.7930 mL | 1.5859 mL | 3.9649 mL | |
| 80 mM | 0.1189 mL | 0.5947 mL | 1.1895 mL | 2.9736 mL | |
| 100 mM | 0.0952 mL | 0.4758 mL | 0.9516 mL | 2.3789 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Serine Related Classifications
HY-N0650 Related Classifications
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