Antimalarial agent 59
Antimalarial agent 59 is an antimalarial agent. Antimalarial agent 59 inhibits the growth of Chloroquine (HY-17589A)-resistant FcB1 strain of Plasmodium falciparum with an IC50 of 46 nM. Antimalarial agent 59 also shows cytotoxic activity against cancer cells. Antimalarial agent 59 can be used for the researches of malaria and ovarian cancer.
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- CAS No.: 3103602-12-3
- Formule: C17H24O7
- Masse moléculaire:340.37
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Activité biologique
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Chemical Information
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Activité biologique
Antimalarial agent 59 (Compound 5i) (48 h) potently inhibits the growth of Chloroquine (HY-17589A)-resistant FcB1 strain of Plasmodium falciparum with an IC50 of 46 nM and a selectivity index of 232[1].
Antimalarial agent 59 (72 h) inhibits the growth of HeLa cervical cancer cells with an LD50 of 10.85 μM[1].
Antimalarial agent 59 (1-10 μM; 24-72 h) reduces A2780 ovarian cancer cell viability in a concentration- and time-dependent manner, with near-complete inhibition at 10 μM after 48 and 72 h[1].
Antimalarial agent 59 (1-10 μM; 72 h) inhibits the growth of A2780 ovarian cancer cells with an IC50 of 3.82 ± 1.38 μM after 72 h of incubation[1].
Antimalarial agent 59 (1-10 μM; 24-72 h) reduces A549 lung adenocarcinoma cell viability in a concentration- and time-dependent manner, with the strongest inhibition (15.75% viability) observed at 10 μM after 72 h[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A2780 ovarian cancer cells
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Concentration:1, 10 μM
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Incubation Time:24, 48, 72 h
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Result:Reduced cell viability to 67.38% at 1 μM (24 h).
Reduced cell viability to 79.57% at 1 μM (48 h).
Reduced cell viability to 92.20% at 1 μM (72 h).
Reduced cell viability to 2.19% at 10 μM (24 h).
Reduced cell viability to 0.04% at 10 μM (48 h).
Reduced cell viability to 1.03% at 10 μM (72 h).
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Cell Line:A549 lung adenocarcinoma cells
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Concentration:1, 10 μM
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Incubation Time:24, 48, 72 h
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Result:Reduced cell viability to 99.03% at 1 μM (24 h).
Reduced cell viability to 92.09% at 1 μM (48 h).
Reduced cell viability to 97.16% at 1 μM (72 h).
Reduced cell viability to 32.81% at 10 μM (24 h).
Reduced cell viability to 19.87% at 10 μM (48 h).
Reduced cell viability to 15.75% at 10 μM (72 h).
Chemical Information
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CAS No. 3103602-12-3
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Masse moléculaire 340.37
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Formule C17H24O7
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SMILES
COC1=CC=C(C2OOC3(CCC(C)CC3)OO2)C(OC)=C1OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antimalarial agent 59 Related Classifications
HY-181658 Related Classifications
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- Antimalarial agent 59
- 3103602-12-3
- Antimalarial agent59
- Antimalarial agent-59
- Parasite
- malaria
- A549 lung adenocarcinoma cells
- ovarian cancer cells
- Plasmodium falciparum
- HeLa cervical cancer cells
- A2780 ovarian cancer cells
- chloroquine-resistant FcB1 strain
- cervical cancer cells
- ovarian cancer
- Inhibitor
- inhibitor
- inhibit