Apelin-13
Based on 10 publication(s) in Google Scholar
Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome.
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- Pureté: 98.11%
- CAS No.: 217082-58-1
- Formule: C69H111N23O16S
- Masse moléculaire:1550.83
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Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Apelin-13
More- Signal Transduct Target Ther. 2021 Dec 16;6(1):427. [Abstract]
- Int J Nanomedicine. 2024 Sep 7:19:9175-9193. [Abstract]
- Int Immunopharmacol. 2025 Dec 13:169:115969. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Mar 19;1870(4):167125. [Abstract]
- Ren Fail. 2025 Dec;47(1):2480243. [Abstract]
- Stem Cells Int. 2022 Mar 21;2022:3742678. [Abstract]
- Free Radic Res. 2024 Dec 28:1-14. [Abstract]
- Microsc Res Tech. 2024 Jun;87(6):1348-1358. [Abstract]
- SSRN. 2025 Oct 9.
- Ann Transl Med. 2021 Apr;9(8):627. [Abstract]
Customer Validation & Images
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Histological Imaging/Staining
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Cell Proliferation/Viability Assay
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Cell Imaging/Staining
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WB
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Flow Cytometry
Activité biologique
IC50: 0.37 nM (APJ)[1]
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Cell Line
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Type | Value | Description | References |
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| CHO | EC50 |
0.87 nM
Compound: Apelin-13, QRPRLSHKGPMPF
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Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
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[PMID: 24755525] |
Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)[2]
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Dosage:200 µg/kg
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Administration:IP, daily for 4 weeks
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Result:Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.
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Animal Model:Adult Wistar rats (SPF, 8-10 weeks, 240-280 g)[4]
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Dosage:10 and100 μM
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Administration:ICV, single dosage
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Result:Increased the spontaneous discharges in the majority of pallidal neurons.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 217082-58-1
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Appearance Solid
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Masse moléculaire 1550.83
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Formule C69H111N23O16S
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Color White to off-white
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Sequence
Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
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Sequence Shortening
QRPRLSHKGPMPF
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (10)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors. [Abstract]2021 Dec 16;6(1):427. PMID: 34916489 -
Int J Nanomedicine
Apelin-13-Loaded Macrophage Membrane-Encapsulated Nanoparticles for Targeted Ischemic Stroke Therapy via Inhibiting NLRP3 Inflammasome-Mediated Pyroptosis. [Abstract]2024 Sep 7:19:9175-9193. PMID: 39263632 -
Int Immunopharmacol
Apelin-13 regulated thrombotic inflammation and induced homing of EPCs to promote the dissolution and recanalization of deep vein thrombosis. [Abstract]2025 Dec 13:169:115969. PMID: 41391282 -
Biochim Biophys Acta Mol Basis Dis
The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms. [Abstract]2024 Mar 19;1870(4):167125. PMID: 38508477 -
Ren Fail
Apelin-13 exerts protective effects against acute kidney injury by lysosomal function regulation. [Abstract]2025 Dec;47(1):2480243. PMID: 40125924
Apelin-13 purchased from MedChemExpress. Usage Cited in: Ren Fail. 2025 Dec;47(1):2480243. [Abstract]
Apelin-13 (30 μg/kg) treatment improved renal function and reduced tubulointerstitial injury. PAS staining (×200) showed histological changes in the kidneys of each group.
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Stem Cells Int
Apelin-13 Pretreatment Promotes the Cardioprotective Effect of Mesenchymal Stem Cells against Myocardial Infarction by Improving Their Survival. [Abstract]2022 Mar 21;2022:3742678. PMID: 35355588
Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678. [Abstract]
CCK-8 assay showed the cell viability of MSCs with or without Apelin-13 (0.01, 0.05, 0.1, 0.5, and 1 nM) pretreatment for 24 hours under normoxic or SD/H conditions.
Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678. [Abstract]
Representative images of MitoTracker staining and quantitative analysis of the mitochondrial number and mean mitochondrial area in MSCs and Apelin-13 (0.1 nM)-pretreated MSCs under normoxic or SD/H conditions.
Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678. [Abstract]
Western blotting and quantitative analysis of the protein level of Mfn1/2 and p-Drp1 ser616 in MSCs and Apelin-13-pretreated MSCs under normoxia or SD/H challenge.
Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678. [Abstract]
Representative images of Annexin V/PI staining and quantitative analysis of the apoptotic rate in MSCs and Apelin-13 (0.1 nM)-pretreated MSCs under normoxic or SD/H conditions.
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Free Radic Res
Apelin deficiency exacerbates cardiac injury following infarction by accelerating cardiomyocyte ferroptosis. [Abstract]2024 Dec 28:1-14. PMID: 39731709 -
Microsc Res Tech
Apelin-13 alleviates osteoclast formation and osteolysis through Nrf2-pyroptosis pathway. [Abstract]2024 Jun;87(6):1348-1358. PMID: 38380581 -
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Ann Transl Med
Apelin receptor upregulation in spontaneously hypertensive rat contributes to the enhanced vascular smooth muscle cell proliferation by activating autophagy. [Abstract]2021 Apr;9(8):627. PMID: 33987325
Solvant et solubilité
DMSO : 100 mg/mL (64.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Tatemoto, K., Hosoya, M., Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications 251, 471-476 (1998). [Content Brief]
[2]. Li M,et al. Apelin 13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high fat diet. Mol Med Rep. 2018 Dec;18(6):5784-5790. [Content Brief]
[3]. Yamaleyeva LM, et al. Apelin-13 in blood pressure regulation and cardiovascular disease. Curr Opin Nephrol Hypertens. 2016 Sep;25(5):396-403. [Content Brief]
[4]. Wang Y, et al. Apelin-13 regulates electrical activity in the globus pallidus and induces postural changes in rats. Neural Regen Res. 2021 Nov;16(11):2264-2268. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 0.6448 mL | 3.2241 mL | 6.4482 mL | 16.1204 mL |
| 5 mM | 0.1290 mL | 0.6448 mL | 1.2896 mL | 3.2241 mL | |
| 10 mM | 0.0645 mL | 0.3224 mL | 0.6448 mL | 1.6120 mL | |
| 15 mM | 0.0430 mL | 0.2149 mL | 0.4299 mL | 1.0747 mL | |
| 20 mM | 0.0322 mL | 0.1612 mL | 0.3224 mL | 0.8060 mL | |
| 25 mM | 0.0258 mL | 0.1290 mL | 0.2579 mL | 0.6448 mL | |
| 30 mM | 0.0215 mL | 0.1075 mL | 0.2149 mL | 0.5373 mL | |
| 40 mM | 0.0161 mL | 0.0806 mL | 0.1612 mL | 0.4030 mL | |
| 50 mM | 0.0129 mL | 0.0645 mL | 0.1290 mL | 0.3224 mL | |
| 60 mM | 0.0107 mL | 0.0537 mL | 0.1075 mL | 0.2687 mL |
Apelin-13 Related Classifications
HY-P1944 Related Classifications
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