country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-202191

Copy Link Print Information

(1-Amino-1-phosphonooctyl)phosphonic acid

Name: (1-Amino-1-phosphonooctyl)phosphonic acid
Brand: MedChemExpress
SKU: HY-202191
Price: 350.00 USD
Availability: PreOrder

1 Cited Publications

Avis client

Based on 1 publication(s) in Google Scholar

(1-Amino-1-phosphonooctyl)phosphonic acid is a selective acid sphingomyelinase (aSMase) inhibitor with an IC₅₀ of 40 nM against rat aSMase. (1-Amino-1-phosphonooctyl)phosphonic acid blocks the hydrolysis of sphingomyelin to ceramide and shows no significant inhibition of Mg²⁺-dependent neutral sphingomyelinase (nSMase).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté : 98.5%
CAS No.: 15049-89-5
Formule: C₈H₂₁NO₆P₂
Masse moléculaire:289.20

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

(1-Amino-1-phosphonooctyl)phosphonic acid Chemical Structure

CAS No.: 15049-89-5

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

Acid sphingomyelinase (aSMase)

40 nM (IC₅₀)

Voir tous les produits spécifiques à Isoform Phospholipase :

In Vitro

Lipid Metabolism

(1-Amino-1-phosphonooctyl)phosphonic acid (compound 7b) (20 µM for 3 h) inhibits rat brain aSMase by 93% in a single-point screen^[1].
(1-Amino-1-phosphonooctyl)phosphonic acid (Up to 100 µM) does not substantially inhibit Mg²⁺-dependent nSMase (IC₅₀ >100 µM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 15049-89-5
Appearance Solid
Masse moléculaire 289.20
Formule C₈H₂₁NO₆P₂
Color Yellow to orange
SMILES

O=P(O)(O)C(N)(CCCCCCC)P(=O)(O)O
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

All

Sort by:

Journal Impact Factor

Int Arch Allergy Immunol

Acid Sphingomyelinase-Ceramide Axis Modulation Is Associated with Thymic Stromal Lymphopoietin Release and Epithelial Barrier Dysfunction in an in vitro Type 2 Inflammation Model Relevant to Pediatric Rhinitis. [Abstract]

2026 Aug 3:1. PMID: 42545914

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Roth AG, et al. Potent and selective inhibition of acid sphingomyelinase by bisphosphonates. Angew Chem Int Ed Engl. 2009;48(41):7560-3. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

(1-Amino-1-phosphonooctyl)phosphonic acid

1 Cited Publications

100 mg Obtenir un devis

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

(1-Amino-1-phosphonooctyl)phosphonic acid

Publications Citing Use of MedChemExpress (MCE) (1-Amino-1-phosphonooctyl)phosphonic acid

Voir tous les produits spécifiques à Isoform Phospholipase