BBIQ (GMP)
BBIQ (GMP) is BBIQ (HY-111582) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. BBIQ is a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1 nM. BBIQ is a powerful vaccine adjuvant that enhances innate immune responses.
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- CAS No.: 1229024-57-0
- Formule: C21H22N4
- Masse moléculaire:330.43
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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HY-111582
BBIQTLR7 Agonist -
HY-148068
STING agonist-20STING Agonist -
HY-123942
DiprovocimTLR1/TLR2 Agonist -
HY-P1180A
Pam3CSK4 TFATLR1/2 Agonist -
HY-W250113
Zymosan ATLR2 Agonist -
HY-146244
AgatolimodTLR9 Agonist -
HY-150724
ODN 1018TLR9 Agonist -
HY-150734
ODN 2007TLR Ligand -
HY-121496
3M-011TLR7/8 Agonist -
HY-150748
ODN D-SL01TLR9 Agonist -
HY-150742
ODN 2336TLR9 Agonists
Activité biologique
Description
IC50 & Target
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human TLR7 59.1 nM (EC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| HEK293 | EC50 |
0.0591 μM
Compound: 31
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Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay
Agonist activity at human TLR7 expressed in NF-kappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by reporter gene assay
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[PMID: 20481492] |
Chemical Information
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CAS No. 1229024-57-0
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Masse moléculaire 330.43
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Formule C21H22N4
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SMILES
NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CC4=CC=CC=C4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Saroa R, et al. Efficacy of TLR7 agonistic imidazoquinoline as immunochemotherapeutic agent against P. Berghei ANKA infected rodent host. Bioorg Med Chem Lett. 2019 May 1;29(9):1099-1105. [Content Brief]
[2]. Kaushik D, et al. BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant. Hum Vaccin Immunother. 2020 Apr 16:1-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BBIQ (GMP) Related Classifications
HY-111582G Related Classifications
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