BE21349
BE21349 is a carbonic anhydrase (CA) inhibitor with Ki values of 2090, 17.1, 61.8, and 40.5 nM against hCA I, hCA II, hCA IX, and hCA XII, respectively. BE21349 exhibits submicromolar inhibitory activity against leukemia, non-small cell lung cancer, and melanoma cell lines. BE21349 can be used in cancer-related research such as leukemia, non-small cell lung cancer, and melanoma.
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- Formule: C22H18N4O4S
- Masse moléculaire:434.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Activité biologique
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hCA I 2090 nM (Ki) |
hCA II 17.1 nM (Ki) |
hCA IX 61.8 nM (Ki) |
hCA XII 40.5 nM (Ki) |
BE21349 (0.01-100 μM; 48 h) demonstrates broad, potent antiproliferative activity across the NCI-60 human tumor cell line panel, with submicromolar GI50 values in multiple leukemia, melanoma, central nervous system, and ovarian cell lines, and exhibits both cytostatic (TGI) and cytotoxic (LC50) effects in a large subset of tested cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-60 human tumor cell line panel (9 cancer types: leukemia, nonsmall cell lung cancer, colon, central nervous system, melanoma, ovarian, renal, prostate, breast)
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Concentration:0.01, 0.1, 1, 10 and 100 μM
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Incubation Time:48 h
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Result:Inhibited growth of 55 out of 57 tested cell lines with GI50 values ranging from 0.17−36.31 μM; only ovarian OVCAR-4 and SK-OV-3 had GI50 > 100 μM.
Identified the most sensitive cell line as leukemia SR (GI50 = 0.17 μM).
Observed submicromolar GI50 values in leukemia CCRF-CEM (0.32 μM), HL-60(TB) (0.62 μM), MOLT-4 (0.59 μM), nonsmall cell lung cancer NCI-H322M (0.76 μM), central nervous system SF-268 (0.43 μM), melanoma LOX IMVI (0.44 μM), SK-MEL-2 (0.71 μM), SK-MEL-28 (0.56 μM), SK-MEL-5 (0.74 μM), and ovarian OVCAR-3 (0.29 μM).
Reported TGI values ranging from 0.33−79.43 μM, with 26 cell lines showing TGI < 10 μM.
Observed LC50 values < 100 μM in 18 cell lines, ranging from 0.66-91.2 μM.
Recorded IC50 values < 1 μM in 6 cell lines, with an additional 25 cell lines showing single-digit micromolar IC50 values.
Chemical Information
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Masse moléculaire 434.47
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Formule C22H18N4O4S
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SMILES
O=S(C(C=C1)=CC=C1C(N(C2=O)/N=C/C3=C(C=CC(C)=C3)O)=NC4=C2C=CC=C4)(N)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BE21349 Related Classifications
HY-184660 Related Classifications
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