β-Cryptoxanthin
β-Cryptoxanthin ((3R)-β-Cryptoxanthin) is an orally active carotenoid found in fruits and vegetables such as angerines, red peppers, and pumpkin. β-Cryptoxanthin inhibits prevents osteoclast formation and inhibits bone resorption. β-Cryptoxanthin maintains retinol status in vivo. β-cryptoxanthin shows anti-inflammation and anticancer activity. β-Cryptoxanthin can be used for the researches of osteoporosis and bladder carcer.
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- Pureté: 96.66%
- CAS No.: 472-70-8
- Formule: C40H56O
- Masse moléculaire:552.87
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Human Endogenous Metabolite |
β-Cryptoxanthin inhibits growth, upregulates RARβ mRNA, and transactivates RARE-mediated transcription in BEAS-2B lung epithelial cells in vitro[1].
β-Cryptoxanthin increase calcium content,
protein content, and alkaline phosphatase activity in bone[1].
β-Cryptoxanthin inhibits bone resorption in vitro by preventing osteoclast formation in mouse marrow cultures and inducing caspase-3-dependent apoptosis of mature osteoclastic cells, with synergistic effects alongside zinc[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
β-cryptoxanthin supplementation significantly decreases smoke-induced
squamous metaplasia and inflammation in the lung and lowers tumor necrosis factor a concentrations in lung tissue cells and macrophages in ferrets[1].
β-cryptoxanthin supplementation inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice, while restoring key regulatory gene expression and improving survival[1].
β-cryptoxanthin supplementation inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice[1].
β-Cryptoxanthin (50-500 µg/kg; p.o.; daily; 1 week) increases bone formation markers and prevents bone loss in multiple rat models of osteoporosis, with enhanced efficacy when combined with zinc[1].
β-Cryptoxanthin (0.05-1.75 mg/kg; p.o.; ad libitum in drinking water; 7 days) dose-dependently suppresses psychosocial stress-induced adrenal hypertrophy in male ddY mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rats with osteoporosis (young male, older female)[1]
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Dosage:50, 100, 500 µg/kg
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Administration:Oral; daily; 1 week
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Result:Increased alkaline phosphatase activity and calcium concentrations in diaphyseal and metaphyseal tissues of young male and older female rats.
Prevented bone loss in streptozotocin-diabetic rats and ovariectomized rats.
Inhibited bone resorption.
Enhanced anabolic effects on bone components when combined with zinc sulfate.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 472-70-8
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Appearance Solid
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Masse moléculaire 552.87
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Formule C40H56O
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Color Red to dark red
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SMILES
CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C[C@@H](O)CC2(C)C)=C(C)CCC1
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Synonyms
(3R)-β-Cryptoxanthin
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Pureté et documentation
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Fiche technique (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
β-Cryptoxanthin Related Classifications
HY-108059 Related Classifications
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