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Cat. No.: HY-114641

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BIIL-260

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

BIIL-260 is a potent and long-acting orally active leukotriene B(4) receptor LTB₄ antagonist, with anti-inflammatory activity. BIIL-260 interacts with the LTB₄ receptor in a saturable, reversible, and competitive manner, has high affinity to the LTB₄ receptor on isolated human neutrophil cell membranes with the K_i value of 1.7 nM.

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CAS No.: 204974-93-6
Formule: C₃₀H₃₀N₂O₃
Masse moléculaire:466.57

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

BIIL-260 Chemical Structure

CAS No.: 204974-93-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Pureté et documentation
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Activité biologique

Description

IC₅₀ & Target

Ki: 1.7 nM (LTB₄ receptor)^[1]

Voir tous les produits spécifiques à Isoform Leukotriene Receptor :

In Vitro

BIIL-260 potently inhibits LTB₄-induced intracellular Ca²⁺ release in human neutrophils with the IC₅₀ value of 0.82 nM.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 204974-93-6
Masse moléculaire 466.57
Formule C₃₀H₃₀N₂O₃
SMILES

N=C(N)C1=CC=C(C=C1)OCC2=CC=CC(COC3=CC=C(C=C3)C(C4=CC=C(C=C4)O)(C)C)=C2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Leukoc Biol

Caging giants: Characterizing the molecular mechanisms of neutrophil swarming against Candida albicans hyphae. [Abstract]

2025 Jun 6:qiaf082. PMID: 40476443

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Birke FW, et al. In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. J Pharmacol Exp Ther. 2001 Apr;297(1):458-66. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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BIIL-260

1 Cited Publications

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- In Vitro
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Publications (1)
Pureté et documentation
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BIIL-260

Publications Citing Use of MedChemExpress (MCE) BIIL-260

Voir tous les produits spécifiques à Isoform Leukotriene Receptor

Activité biologique

Chemical Information

Publications (1)

Pureté et documentation

Références

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BIIL-260 Related Classifications

HY-114641 Related Classifications