BMS-341400
BMS-341400 is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM. BMS-341400 reduces the degradation of cyclic guanosine monophosphate (cGMP), thereby enhancing nitric oxide (NO)-mediated relaxation of the smooth muscle of the corpus cavernosum and promoting erection. BMS-341400 can be used to study erectile dysfunction.
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- CAS No.: 296250-53-8
- Formule: C23H22ClN9O2
- Masse moléculaire:491.93
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
PDE5 0.3 nM (IC50) |
In Vitro
BMS-341400 (Compound 6) effectively enhanced the relaxation of the smooth muscle in the isolated tissue of the rabbit penile corpus cavernosum, with its EC₅₀ value being 13 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | F | T1/2 |
|---|---|---|---|---|
| Dog | 5.1 μmol/Kg | p.o. | 42 % | 2 h |
| Rat | 2 μmol/Kg | p.o. | 29 % | 1.2 h |
In Vivo
BMS-341400 (10-250 mg/kg) demonstrates excellent safety in rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Anesthesia-induced male rabbit model[1]
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Dosage:10, 30, 100, 300, and 1000 nmol/kg
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Administration:Intravenous injection (i.v.), single dose
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Result:Had an equivalent efficacy in promoting erections in the body as Sildenafil (HY-15025).
Chemical Information
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CAS No. 296250-53-8
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Masse moléculaire 491.93
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Formule C23H22ClN9O2
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SMILES
CCN1C2=C(C3=C(C(N4C=C(C(NC)=O)N=C4)=NN=C3NCC5=CC(Cl)=C(OC)C=C5)C=N2)C=N1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-341400 Related Classifications
HY-107022 Related Classifications
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