Caerulein acetate
145 Cited Publications
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Based on 145 publication(s) in Google Scholar
Caerulein acetate is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide acetate is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts.
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- CAS No.: 2760881-68-1
- Formule: C60H77N13O23S2
- Masse moléculaire:1412.46
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) Caerulein acetate
More- Nat Nanotechnol. 2025 Aug 11. [Abstract]
- Gut. 2024 Jun 6;73(7):1142-1155. [Abstract]
- Cancer Res. 2025 Nov 6. [Abstract]
- Cell Discov. 2023 Jan 3;9(1):1. [Abstract]
- J Exp Clin Cancer Res. 2021 Jan 9;40(1):25. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(24):e20739. [Abstract]
- Adv Sci (Weinh). 2026 Jan 22:e17877. [Abstract]
- Adv Sci (Weinh). 2025 Apr;12(13):e2413925. [Abstract]
- Sci Adv. 2020 Aug 5;6(32):eaba8415. [Abstract]
- Cell Death Differ. 2026 Jun 3. [Abstract]
- Chem Eng J. 15 October 2022, 136792.
- Cell Death Dis. 2025 Jul 27;16(1):566. [Abstract]
- Cell Death Dis. 2025 May 15;16(1):385. [Abstract]
- Cell Death Dis. 2023 Feb 24;14(2):155. [Abstract]
- Cell Death Dis. 2021 Oct 11;12(10):928. [Abstract]
- Cell Death Dis. 2021 Mar 15;12(3):273. [Abstract]
- Cancer Lett. 2023 Nov 28:577:216444. [Abstract]
- Cell Commun Signal. 2025 Sep 2;23(1):388. [Abstract]
- J Neuroinflammation. 2026 May 25. [Abstract]
- Phytomedicine. 2026 Jun 24:159:158478. [Abstract]
- Acta Pharmacol Sin. 2026 Jan 16. [Abstract]
- Biomater Res. 2026 May 18:30:0369. [Abstract]
- J Transl Med. 2024 Dec 20;22(1):1124. [Abstract]
- Apoptosis. 2025 Feb;30(1-2):149-166. [Abstract]
- Int J Mol Med. 2025 Feb;55(2):25. [Abstract]
- Int J Mol Med. 2022 Jul;50(1):89. [Abstract]
- Mol Med. 2025 Jan 24;31(1):24. [Abstract]
- Mol Med. 2022 Sep 6;28(1):106. [Abstract]
- Cell Mol Gastroenterol Hepatol. 2026 May 27:101819. [Abstract]
- Free Radic Biol Med. 2025 Nov 23:243:398-413. [Abstract]
- Free Radic Biol Med. 2025 Mar 16:230:294-308. [Abstract]
- Free Radic Biol Med. 2021 Sep:173:29-40. [Abstract]
- Free Radic Biol Med. 2021 Feb 1:163:379-391. [Abstract]
- Am J Chin Med. 2022;50(8):2185-2197. [Abstract]
- Cell Rep. 2025 Nov 25;44(11):116487. [Abstract]
- Cell Rep. 2025 Jun 27;44(7):115925. [Abstract]
- World J Gastroenterol. 2023 Aug 14;29(30):4642-4656. [Abstract]
- Br J Pharmacol. 2025 Aug 21. [Abstract]
- Br J Pharmacol. 2024 Oct;181(20):4067-4084. [Abstract]
- Anal Chem. 2020 Mar 17;92(6):4419-4426. [Abstract]
- Front Immunol. 2019 May 3:10:980. [Abstract]
- J Ethnopharmacol. 2026 Mar 1:358:121001. [Abstract]
- J Ethnopharmacol. 2025 Apr 9:345:119551. [Abstract]
- J Ethnopharmacol. 2024 Mar 25:322:117590. [Abstract]
- JCI Insight. 2021 Jan 25;6(2):e138584. [Abstract]
- CNS Neurosci Ther. 2025 Mar;31(3):e70313. [Abstract]
- Biochem Pharmacol. 2019 Mar:161:149-162. [Abstract]
- Food Funct. 2025 Dec 8;16(24):9628-9641. [Abstract]
- Bioresour Bioprocess. 2025 Dec 3;12(1):139. [Abstract]
- Food Funct. 2020 Jan 29;11(1):456-471. [Abstract]
- Inflamm Res. 2024 Oct;73(10):1803-1817. [Abstract]
- Eur J Pharmacol. 2025 Jul 5:998:177536. [Abstract]
- Eur J Pharmacol. 2025 May 5:994:177314. [Abstract]
- J Gastroenterol. 2024 Sep;59(9):869-879. [Abstract]
- Int Immunopharmacol. 2026 Sep 1:184:116919. [Abstract]
- Int Immunopharmacol. 2026 Jul 1:180:116695. [Abstract]
- Biomolecules. 2026 Jun 20;16(6):917. [Abstract]
- Int Immunopharmacol. 2026 Apr 26:180:116680. [Abstract]
- Int Immunopharmacol. 2025 Jun 26:159:114948. [Abstract]
- Int J Mol Sci. 2025 Apr 8;26(8):3482. [Abstract]
- Int J Mol Sci. 2025 Feb 22;26(5):1899. [Abstract]
- Int Immunopharmacol. 2024 Oct 27;143(Pt 2):113490. [Abstract]
- Int Immunopharmacol. 2024 Oct 31;143(Pt 3):113485. [Abstract]
- Int Immunopharmacol. 2024 Aug 20:137:112450. [Abstract]
- Int Immunopharmacol. 2024 Feb 15:128:111495. [Abstract]
- Biomolecules. 2022 Dec 30;13(1):78. [Abstract]
- Int Immunopharmacol. 2022 Jul:108:108777. [Abstract]
- Int Immunopharmacol. 2021 May:94:107496. [Abstract]
- Int J Mol Sci. 2021 Mar 30;22(7):3593. [Abstract]
- Am J Physiol Cell Physiol. 2026 Aug 1;331(2):C252-C266. [Abstract]
- Inflammation. 2026 Jan 22;49(1):59. [Abstract]
- mBio. 2025 Aug 8:e0003125. [Abstract]
- Inflammation. 2025 Feb 7. [Abstract]
- Front Pharmacol. 2020 Jun 10:11:859. [Abstract]
- Front Pharmacol. 2020 May 8:11:618. [Abstract]
- Front Chem. 2020 Oct 7;8:720. [Abstract]
- J Nutr Biochem. 2026 Apr:150:110225. [Abstract]
- Chem Biol Interact. 2025 Sep 26:111758. [Abstract]
- mSystems. 2022 May 2;e0150721. [Abstract]
- Molecules. 2022 Apr 27;27(9):2783. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Mar;1871(3):167613. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2024 Apr;1870(4):167088. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2022 Dec 1;1868(12):166490. [Abstract]
- Mol Med Rep. 2021 Nov;24(5):785. [Abstract]
- Sci Rep. 2026 Feb 6;16(1):7540. [Abstract]
- Sci Rep. 2024 Sep 14;14(1):21491. [Abstract]
- Eur J Med Res. 2025 Jan 17;30(1):35. [Abstract]
- Cell Signal. 2025 Dec:136:112123. [Abstract]
- Cell Signal. 2025 Jan:125:111504. [Abstract]
- Cell Signal. 2024 Apr:116:111033. [Abstract]
- J Cell Mol Med. 2020 Jan;24(2):1488-1503. [Abstract]
- J Inflamm Res. 2026 Mar 12:19:572609. [Abstract]
- J Inflamm Res. 2026 Jan 16;19:1-14.
- J Inflamm Res. 2025 Dec 22:18:18009-18024. [Abstract]
- J Inflamm Res. 2024 Nov 2:17:8099-8115. [Abstract]
- J Inflamm Res. 2023 Oct 6:16:4425-4439. [Abstract]
- Mol Nutr Food Res. 2025 Oct 29:e70304. [Abstract]
- Biomedicines. 2022 Oct 12;10(10):2543. [Abstract]
- Biosci Rep. 2019 Jul 2;39(7):BSR20190516. [Abstract]
- FASEB J. 2026 Mar 31;40(6):e71679. [Abstract]
- Drug Dev Res. 2025 Aug;86(5):e70140. [Abstract]
- J Cell Physiol. 2019 Dec;234(12):21988-21998. [Abstract]
- AMB Express. 2026 May 20. [Abstract]
- J Funct Foods. 2026 May 4;141:107327.
- Pancreatology. 2025 Sep 20:S1424-3903(25)00615-5. [Abstract]
- Pancreatology. 2024 Jun;24(4):528-537. [Abstract]
- Pancreatology. 2022 Nov;22(7):917-924. [Abstract]
- J Funct Foods. September 2022, 105179.
- Pancreatology. 2021 Aug;21(5):870-883. [Abstract]
- Mol Immunol. 2018 Nov:103:78-88. [Abstract]
- Toxicol Appl Pharmacol. 2024 Nov:492:117136. [Abstract]
- Exp Cell Res. 2019 Nov 1;384(1):111606. [Abstract]
- Thromb Res. 2025 Aug:252:109363. [Abstract]
- Arch Immunol Ther Exp (Warsz). 2025 Jun 5;73(1). [Abstract]
- Arch Immunol Ther Exp (Warsz). 2025 Apr 16;73(1). [Abstract]
- Pflugers Arch. 2019 Dec;471(11-12):1519-1527. [Abstract]
- Kaohsiung J Med Sci. 2025 Jan;41(1):e12911. [Abstract]
- J Gene Med. 2024 Apr;26(4):e3683. [Abstract]
- Dig Dis Sci. 2022 Sep;67(9):4471-4483. [Abstract]
- J Dig Dis. 2021 Jun;22(6):363-372. [Abstract]
- Pancreas. 2021 Feb 1;50(2):243-250. [Abstract]
- Pancreas. 2020 Jan;49(1):111-119. [Abstract]
- Exp Ther Med. 2019 Aug;18(2):1246-1252. [Abstract]
- Exp Anim. 2023 Aug 7;72(3):379-388. [Abstract]
- Braz J Med Biol Res. 2020;53(10):e9183. [Abstract]
- Can J Physiol Pharmacol. 2019 Jan;97(1):15-22. [Abstract]
- Am J Transl Res. 2018 Feb 15;10(2):402-410. [Abstract]
- J Clin Pharm Ther. 2023 Seo 4.
- Turk J Biochem. 2021 Mar 1.
- SSRN. 2025 Dec 17.
- bioRxiv. 2025 Aug 20.
- SSRN. 2025 Jan 30.
- Res Sq. 2024 Jun 20.
- Heliyon. 2024 Jan 13;10(2):e24461. [Abstract]
- bioRxiv. 2023 Sep 28.
- SSRN. 2023 Sep 11.
- bioRxiv. 2023 Sep 13.
- SSRN. 2023 Mar 13.
- Western University. Physiology and Pharmacology. 2022 Oct.
- Oxid Med Cell Longev. 2022 Jul 26:2022:4499219. [Abstract]
- Research Square Preprint. 2022 Jan.
- Environ Toxicol. 2021 Dec;36(12):2392-2403. [Abstract]
- Biomed Pharmacother. 2020 Jul:127:110116. [Abstract]
- bioRxiv. 2020 Mar.
- Oxid Med Cell Longev. 2019 Nov 15:2019:6181754. [Abstract]
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Activité biologique
Description
Caerulein acetate is a decapeptide and a potent cholecystokinin receptor agonist. Ceruletide acetate is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts[1].
Chemical Information
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CAS No. 2760881-68-1
-
Masse moléculaire 1412.46
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Formule C60H77N13O23S2
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Sequence
{Pyr}-Gln-Asp-{Tyr
}-Thr-Gly-Trp-Met-Asp-Phe-NH2 -
Sequence Shortening
{Pyr}-QD-{Tyr
}-TGWMDF-NH2 -
Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (145)
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Journal Impact Factor
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Journal Impact Factor
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Most Recent
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Nat Nanotechnol
Annexin A1 mRNA-loaded liposomes alleviate acute pancreatitis by suppressing STING pathway and promoting efferocytosis in macrophages. [Abstract]2025 Aug 11. PMID: 40789923 -
Gut
Pancreas-directed AAV8 -hSPINK1 gene therapy safely and effectively protects against pancreatitis in mice. [Abstract]2024 Jun 6;73(7):1142-1155. PMID: 38553043 -
Cancer Res
USP20-Driven Cholesterol Metabolism Links Inflammatory Signaling to Malignancy and Stromal Co-evolution in Pancreatic Cancer. [Abstract]2025 Nov 6. PMID: 41196022 -
Cell Discov
Use of a dual genetic system to decipher exocrine cell fate conversions in the adult pancreas. [Abstract]2023 Jan 3;9(1):1. PMID: 36596774 -
J Exp Clin Cancer Res
2021 Jan 9;40(1):25. PMID: 33422093 -
Adv Sci (Weinh)
TGM2 Aggravates Acute Pancreatitis by Impairing Macrophage Efferocytosis Through Inhibition of the STAT6-GAS6 Axis. [Abstract]2026 Apr;13(24):e20739. PMID: 41703992 -
Adv Sci (Weinh)
Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2-Mediated Mitochondrial Stabilization. [Abstract]2026 Jan 22:e17877. PMID: 41572443 -
Adv Sci (Weinh)
Nanomedicine Penetrating Blood-Pancreas Barrier for Effective Treatment of Acute Pancreatitis. [Abstract]2025 Apr;12(13):e2413925. PMID: 39950925 -
Sci Adv
Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo. [Abstract]2020 Aug 5;6(32):eaba8415. PMID: 32821827 -
Cell Death Differ
Cell death-induced release of the pro-aging protein acyl CoA binding protein (ACBP) into the circulation. [Abstract]2026 Jun 3. PMID: 42236908 -
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Cell Death Dis
Repurposing BCL2 inhibitors: Venetoclax protects against acinar cell necrosis in acute pancreatitis by promoting apoptosis. [Abstract]2025 Jul 27;16(1):566. PMID: 40715042 -
Cell Death Dis
Mechanistic insights into the role of FAT10 in modulating NCOA4-mediated ferroptosis in pancreatic acinar cells during acute pancreatitis. [Abstract]2025 May 15;16(1):385. PMID: 40374601 -
Cell Death Dis
2023 Feb 24;14(2):155. PMID: 36828808 -
Cell Death Dis
Sitagliptin activates the p62-Keap1-Nrf2 signalling pathway to alleviate oxidative stress and excessive autophagy in severe acute pancreatitis-related acute lung injury. [Abstract]2021 Oct 11;12(10):928. PMID: 34635643 -
Cell Death Dis
Neddylation pathway alleviates chronic pancreatitis by reducing HIF1α-CCL5-dependent macrophage infiltration. [Abstract]2021 Mar 15;12(3):273. PMID: 33723230 -
Cancer Lett
POH1 facilitates pancreatic carcinogenesis through MYC-driven acinar-to-ductal metaplasia and is a potential therapeutic target. [Abstract]2023 Nov 28:577:216444. PMID: 37844756 -
Cell Commun Signal
AXL and MERTK facilitate tissue repair in severe acute pancreatitis via a CCR5-dependent neutrophil and macrophage crosstalk. [Abstract]2025 Sep 2;23(1):388. PMID: 40898178 -
J Neuroinflammation
PVNOXT regulates acinar cell-mediated inflammatory response via DMVACh projections to the acinar cell. [Abstract]2026 May 25. PMID: 42186091 -
Phytomedicine
β-elemene directly targets IL-17RA in macrophages to inhibit inflammation and attenuate acute pancreatitis. [Abstract]2026 Jun 24:159:158478. PMID: 42365689 -
Acta Pharmacol Sin
A sinomenine derivative protects life-threatening inflammatory injuries via covalently binding to a novel allosteric inhibition site of IRF3. [Abstract]2026 Jan 16. PMID: 41545756 -
Biomater Res
Biomimetic Layered Double Hydroxide-Molybdenum Disulfide Encapsulated with Bovine Serum Albumin: A Multifaceted Nanotherapy for Inflammatory Bowel Disease. [Abstract]2026 May 18:30:0369. PMID: 42158621 -
J Transl Med
Conjugated bile acids alleviate acute pancreatitis through inhibition of TGR5 and NLRP3 mediated inflammation. [Abstract]2024 Dec 20;22(1):1124. PMID: 39707318 -
Apoptosis
MRG15 promotes cell apoptosis through inhibition of mitophagy in hyperlipidemic acute pancreatitis. [Abstract]2025 Feb;30(1-2):149-166. PMID: 39487311 -
Int J Mol Med
Artesunate protects against a mouse model of cerulein and lipopolysaccharide‑induced acute pancreatitis by inhibiting TLR4‑dependent autophagy. [Abstract]2025 Feb;55(2):25. PMID: 39635846 -
Int J Mol Med
Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2/HO‑1‑mediated ferroptosis pathway. [Abstract]2022 Jul;50(1):89. PMID: 35582998 -
Mol Med
Disrupting of IGF2BP3-stabilized CLDN11 mRNA by TNF-α increases intestinal permeability in obesity-related severe acute pancreatitis. [Abstract]2025 Jan 24;31(1):24. PMID: 39856555 -
Mol Med
Acid ceramidase targeting pyruvate kinase affected trypsinogen activation in acute pancreatitis. [Abstract]2022 Sep 6;28(1):106. PMID: 36068514 -
Cell Mol Gastroenterol Hepatol
Triggering Receptor Expressed on Myeloid Cells 2+ Macrophages Promote Pancreatic Regeneration Through Cholesterol-Metabolism Reprogramming and Hedgehog Signaling Activation Following Acute Pancreatitis. [Abstract]2026 May 27:101819. PMID: 42208763 -
Free Radic Biol Med
TFEB-nuclear translocation promotes BNIP3-mediated mitophagy and alleviates oxidative stress and ferroptosis in acute pancreatitis. [Abstract]2025 Nov 23:243:398-413. PMID: 41290101 -
Free Radic Biol Med
Nrf2 ameliorates defective autophagic processes and thereby inhibits ferroptosis in acute pancreatitis by suppressing Beclin1-Slc7a11 complex formation. [Abstract]2025 Mar 16:230:294-308. PMID: 39947493 -
Free Radic Biol Med
Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis. [Abstract]2021 Sep:173:29-40. PMID: 34246777 -
Free Radic Biol Med
The LipoxinA4 receptor agonist BML-111 ameliorates intestinal disruption following acute pancreatitis through the Nrf2-regulated antioxidant pathway. [Abstract]2021 Feb 1:163:379-391. PMID: 33383086 -
Am J Chin Med
Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-κ B Signaling Pathway. [Abstract]2022;50(8):2185-2197. PMID: 36222121 -
Cell Rep
Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas. [Abstract]2025 Nov 25;44(11):116487. PMID: 41166312 -
Cell Rep
Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation. [Abstract]2025 Jun 27;44(7):115925. PMID: 40580477 -
World J Gastroenterol
Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments. [Abstract]2023 Aug 14;29(30):4642-4656. PMID: 37662862 -
Br J Pharmacol
E3 ubiquitin ligase Pellino1 suppresses acinar cell necroptosis and alleviates severe acute pancreatitis by promoting ubiquitin-dependent receptor-interacting protein kinase 3 (RIP3) degradation. [Abstract]2025 Aug 21. PMID: 40842247 -
Br J Pharmacol
IDH2-NADPH pathway protects against acute pancreatitis via suppressing acinar cell ferroptosis. [Abstract]2024 Oct;181(20):4067-4084. PMID: 39072736 -
Anal Chem
Molecular Imaging and In Situ Quantitative Profiling of Fatty Acid Synthase with a Chemical Probe. [Abstract]2020 Mar 17;92(6):4419-4426. PMID: 32053360 -
Front Immunol
TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-β/Interferon-α/β Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model. [Abstract]2019 May 3:10:980. PMID: 31130960 -
J Ethnopharmacol
Chaihu Guizhi Ganjiang decoction attenuates chronic pancreatitis by suppressing acinar cell ferroptosis via regulating p53/SLC7A11/GPX4 pathway. [Abstract]2026 Mar 1:358:121001. PMID: 41354015 -
J Ethnopharmacol
Kinsenoside alleviates experimental acute pancreatitis by suppressing M1 macrophage polarization via the TLR4/STAT1 signaling pathway. [Abstract]2025 Apr 9:345:119551. PMID: 39999939 -
J Ethnopharmacol
Bioinformatics analyses of infiltrating immune cell participation on pancreatic ductal adenocarcinoma progression and in vivo experiment of the therapeutic effect of Shuangshen granules. [Abstract]2024 Mar 25:322:117590. PMID: 38113986 -
JCI Insight
Dysregulated SREBP1c/miR-153 signaling induced by hypertriglyceridemia worsens acute pancreatitis and delays tissue repair. [Abstract]2021 Jan 25;6(2):e138584. PMID: 33491670 -
CNS Neurosci Ther
Upregulation of NR2B Subunits of NMDA Receptors in the Lateral Parabrachial Nucleus Contributes to Chronic Pancreatitis Pain. [Abstract]2025 Mar;31(3):e70313. PMID: 40022510 -
Biochem Pharmacol
Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway. [Abstract]2019 Mar:161:149-162. PMID: 30684465 -
Food Funct
Effects of kefirs made from whole milk or whey on the pancreas-intestine axis in a mouse model of acute pancreatitis. [Abstract]2025 Dec 8;16(24):9628-9641. PMID: 41307507 -
Bioresour Bioprocess
Astragalin attenuates caerulein-induced acute pancreatitis by targeting the NLRP3 signaling pathway and gut microbiota. [Abstract]2025 Dec 3;12(1):139. PMID: 41335362 -
Food Funct
Ginsenoside Rk1 induces apoptosis and downregulates the expression of PD-L1 by targeting the NF-κB pathway in lung adenocarcinoma. [Abstract]2020 Jan 29;11(1):456-471. PMID: 31830168 -
Inflamm Res
2024 Oct;73(10):1803-1817. PMID: 39231819 -
Eur J Pharmacol
Rutin protects the pancreas from inflammatory injury and oncogene-driven tumorigenesis by inhibiting acinar to ductal metaplasia. [Abstract]2025 Jul 5:998:177536. PMID: 40120793 -
Eur J Pharmacol
Octreotide attenuates experimental severe acute pancreatitis through inhibiting pyroptosis and modulating intestinal homeostasis. [Abstract]2025 May 5:994:177314. PMID: 39922420 -
J Gastroenterol
Heparan sulfate acts as an activator of the NLRP3 inflammasome promoting inflammatory response in the development of acute pancreatitis. [Abstract]2024 Sep;59(9):869-879. PMID: 38864913 -
Int Immunopharmacol
The gut microbial metabolite phenylacetylglutamine exacerbates severe acute pancreatitis by promoting ferroptosis and TLR4/NF-κB signaling pathways. [Abstract]2026 Sep 1:184:116919. PMID: 42208327 -
Int Immunopharmacol
Cathepsin B regulated via TFEB and lysosomal membrane permeabilization in adipose tissue macrophages aggravates obesity-related severe acute pancreatitis. [Abstract]2026 Jul 1:180:116695. PMID: 42019387 -
Biomolecules
Alginate Oligosaccharide Alleviates Severe Acute Pancreatitis in Mice via Suppression of Oxidative Stress, Inflammation and Modulation of Intestinal Epithelial Barrier Integrity. [Abstract]2026 Jun 20;16(6):917. PMID: 42352383 -
Int Immunopharmacol
Identifying cathepsin B as a key regulator of programmed cell death in acute pancreatitis. [Abstract]2026 Apr 26:180:116680. PMID: 42044578 -
Int Immunopharmacol
Network pharmacology analysis reveals that coumestrol targets ZYX to inhibit ferroptosis and alleviate acute pancreatitis. [Abstract]2025 Jun 26:159:114948. PMID: 40414075 -
Int J Mol Sci
CD36 Induces Inflammation by Promoting Ferroptosis in Pancreas, Epididymal Adipose Tissue, and Adipose Tissue Macrophages in Obesity-Related Severe Acute Pancreatitis. [Abstract]2025 Apr 8;26(8):3482. PMID: 40331957 -
Int J Mol Sci
MGST1 Protects Pancreatic Ductal Cells from Inflammatory Damage in Acute Pancreatitis by Inhibiting Ferroptosis: Bioinformatics Analysis with Experimental Validation. [Abstract]2025 Feb 22;26(5):1899. PMID: 40076525 -
Int Immunopharmacol
Micheliolide ameliorates severe acute pancreatitis in mice through potentiating Nrf2-mediated anti-inflammation and anti-oxidation effects. [Abstract]2024 Oct 27;143(Pt 2):113490. PMID: 39467351 -
Int Immunopharmacol
ATP citrate lyase ablation hampers exocrine regeneration via TLR4/NF-kappaB signaling after acute pancreatitis in mice. [Abstract]2024 Oct 31;143(Pt 3):113485. PMID: 39486178 -
Int Immunopharmacol
Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways. [Abstract]2024 Aug 20:137:112450. PMID: 38906007 -
Int Immunopharmacol
METTL14 depletion ameliorates ferroptosis in severe acute pancreatitis by increasing the N6-methyladenosine modification of ACSL4 and STA1. [Abstract]2024 Feb 15:128:111495. PMID: 38237228 -
Biomolecules
Integration of scRNA-Seq and Bulk RNA-Seq Reveals Molecular Characterization of the Immune Microenvironment in Acute Pancreatitis. [Abstract]2022 Dec 30;13(1):78. PMID: 36671463 -
Int Immunopharmacol
GDF11 ameliorates severe acute pancreatitis through modulating macrophage M1 and M2 polarization by targeting the TGFβR1/SMAD-2 pathway. [Abstract]2022 Jul:108:108777. PMID: 35461108 -
Int Immunopharmacol
Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis. [Abstract]2021 May:94:107496. PMID: 33639565 -
Int J Mol Sci
Poly(ADP-Ribose) Polymerase 1 Promotes Inflammation and Fibrosis in a Mouse Model of Chronic Pancreatitis. [Abstract]2021 Mar 30;22(7):3593. PMID: 33808340 -
Am J Physiol Cell Physiol
Elevated circulating bile acids alleviate acute pancreatitis by restoring mitochondrial function via acinar cell uptake. [Abstract]2026 Aug 1;331(2):C252-C266. PMID: 42297571 -
Inflammation
A Melittin-Derived Lead Compound Ameliorates Severe Acute Pancreatitis by Restoring Oxidative Homeostasis and Macrophage Metabolism. [Abstract]2026 Jan 22;49(1):59. PMID: 41569335 -
mBio
Structural insights into manganese-dependent arylsulfatase from Enterococcus faecium and its catalytic promiscuity. [Abstract]2025 Aug 8:e0003125. PMID: 40778759 -
Inflammation
4-octyl Itaconate Attenuates Acute Pancreatitis and Associated Lung Injury by Suppressing Ferroptosis in Mice. [Abstract]2025 Feb 7. PMID: 39920558 -
Front Pharmacol
Mogroside IIE Inhibits Digestive Enzymes via Suppression of Interleukin 9/Interleukin 9 Receptor Signalling in Acute Pancreatitis. [Abstract]2020 Jun 10:11:859. PMID: 32587518 -
Front Pharmacol
BRD4 Inhibition Protects Against Acute Pancreatitis Through Restoring Impaired Autophagic Flux. [Abstract]2020 May 8:11:618. PMID: 32457617 -
Front Chem
Porous COS@SiO2 Nanocomposites Ameliorate Severe Acute Pancreatitis and Associated Lung Injury by Regulating the Nrf2 Signaling Pathway in Mice. [Abstract]2020 Oct 7;8:720. PMID: 33134248 -
J Nutr Biochem
2026 Apr:150:110225. PMID: 41352543 -
Chem Biol Interact
Mechanisms and targeted prevention of chronic pancreatitis-acinar to ductal metaplasia caused by a low concentration of di-(2-ethylhexyl)-phthalate. [Abstract]2025 Sep 26:111758. PMID: 41016453 -
mSystems
2022 May 2;e0150721. PMID: 35491818 -
Molecules
Beneficial Effect of Kidney Bean Resistant Starch on Hyperlipidemia-Induced Acute Pancreatitis and Related Intestinal Barrier Damage in Rats. [Abstract]2022 Apr 27;27(9):2783. PMID: 35566136 -
Biochim Biophys Acta Mol Basis Dis
SIRT5 mediated succinylation of SUCLA2 regulates TCA cycle dysfunction and mitochondrial damage in pancreatic acinar cells in acute pancreatitis. [Abstract]2025 Mar;1871(3):167613. PMID: 39643219 -
Biochim Biophys Acta Mol Basis Dis
Pyrazole derivative Z10 ameliorates acute pancreatitis by inhibiting the ERK/Ddt pathway. [Abstract]2024 Apr;1870(4):167088. PMID: 38401696 -
Biochim Biophys Acta Mol Basis Dis
AXL and MERTK receptor tyrosine kinases inhibition protects against pancreatic necrosis via selectively limiting CXCL2-related neutrophil infiltration. [Abstract]2022 Dec 1;1868(12):166490. PMID: 35841983 -
Mol Med Rep
Emodin inhibits the progression of acute pancreatitis via regulation of lncRNA TUG1 and exosomal lncRNA TUG1. [Abstract]2021 Nov;24(5):785. PMID: 34498715 -
Sci Rep
IL-18 promotes pancreatic fibrosis via release of IL-4 from pancreatic stellate cells and induces macrophage M2 polarization. [Abstract]2026 Feb 6;16(1):7540. PMID: 41651972 -
Sci Rep
Integrating metagenomics with metabolomics for gut microbiota and metabolites profiling in acute pancreatitis. [Abstract]2024 Sep 14;14(1):21491. PMID: 39277616 -
Eur J Med Res
Alcohol promotes CPT1A-induced lipid metabolism disorder to sentinel-regulate acute pancreatitis. [Abstract]2025 Jan 17;30(1):35. PMID: 39819476 -
Cell Signal
Endoplasmic reticulum stress regulates intestinal motility in acute pancreatitis by regulating the expression and phosphorylation of nNOS through IRE1α/XBP1s-PI3K/Akt signaling axis. [Abstract]2025 Dec:136:112123. PMID: 40930473 -
Cell Signal
Hyperlipidemia exacerbates acute pancreatitis via interactions between P38MAPK and oxidative stress. [Abstract]2025 Jan:125:111504. PMID: 39505288 -
Cell Signal
E3 ubiquitin ligase FBXW11 as a novel inflammatory biomarker is associated with immune infiltration and NF-κB pathway activation in pancreatitis and pancreatic cancer. [Abstract]2024 Apr:116:111033. PMID: 38182068 -
J Cell Mol Med
Hic-5 deficiency protects cerulein-induced chronic pancreatitis via down-regulation of the NF-κB (p65)/IL-6 signalling pathway. [Abstract]2020 Jan;24(2):1488-1503. PMID: 31797546 -
J Inflamm Res
Celastrol Mitigates Acute Pancreatitis Associated Inflammation by Modulating the IL-34/CSF-1R Axis and Suppressing NF-κB/ERK Signaling. [Abstract]2026 Mar 12:19:572609. PMID: 41847424 -
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J Inflamm Res
The Effects of Da-Chai-Hu Decoction Alleviating Pancreatic Exocrine Dysfunction by Inhibiting Endoplasmic Reticulum Stress of Acinar Cell in Mice with Chronic Pancreatitis. [Abstract]2025 Dec 22:18:18009-18024. PMID: 41458358 -
J Inflamm Res
Identifying the ceRNA Regulatory Network in Early-Stage Acute Pancreatitis and Investigating the Therapeutic Potential of NEAT1 in Mouse Models. [Abstract]2024 Nov 2:17:8099-8115. PMID: 39507263 -
J Inflamm Res
An in-Depth Exploration of the Genetic Interaction Network Between Ferroptosis and Acute Pancreatitis. [Abstract]2023 Oct 6:16:4425-4439. PMID: 37822529 -
Mol Nutr Food Res
Modulation of Intestinal Microbiota Through Kefir-Based Beverages in a Murine Model of Acute Pancreatitis. [Abstract]2025 Oct 29:e70304. PMID: 41159601 -
Biomedicines
2022 Oct 12;10(10):2543. PMID: 36289805 -
Biosci Rep
CaMKII/proteasome/cytosolic calcium/cathepsin B axis was present in tryspin activation induced by nicardipine. [Abstract]2019 Jul 2;39(7):BSR20190516. PMID: 31221819 -
FASEB J
Effect of Diosmetin on Gut Microbiota and Serum Metabolites in Acute Pancreatitis Mice: A Metagenomic and Metabolomic Study. [Abstract]2026 Mar 31;40(6):e71679. PMID: 41854683 -
Drug Dev Res
Betulinic Acid Alleviates Acute Pancreatitis by Promoting SIRT1-PINK1-Mediated Mitophagy in Acinar Cells. [Abstract]2025 Aug;86(5):e70140. PMID: 40787703 -
J Cell Physiol
Restoration of p53 acetylation by HDAC inhibition permits the necrosis/apoptosis switch of pancreatic ainar cell during experimental pancreatitis in mice. [Abstract]2019 Dec;234(12):21988-21998. PMID: 31058328 -
AMB Express
Odoribacter laneus protects intestinal barrier by bile acid-FXR axis in acute pancreatitis. [Abstract]2026 May 20. PMID: 42162499 -
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Pancreatology
Elevated expression of circular RNA circ0001415 attenuates acinar cell pyroptosis during acute pancreatitis. [Abstract]2025 Sep 20:S1424-3903(25)00615-5. PMID: 41006189 -
Pancreatology
Deletion of myeloid-specific Orai1 calcium channel does not affect pancreatic tissue damage in experimental acute pancreatitis. [Abstract]2024 Jun;24(4):528-537. PMID: 38637233 -
Pancreatology
2022 Nov;22(7):917-924. PMID: 35989220 -
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Pancreatology
Inhibition of nicotinamide phosphoribosyltransferase protects against acute pancreatitis via modulating macrophage polarization and its related metabolites. [Abstract]2021 Aug;21(5):870-883. PMID: 33810973 -
Mol Immunol
LipoxinA4 attenuates acute pancreatitis-associated acute lung injury by regulating AQP-5 and MMP-9 expression, anti-apoptosis and PKC/SSeCKS-mediated F-actin activation. [Abstract]2018 Nov:103:78-88. PMID: 30219663 -
Toxicol Appl Pharmacol
Lonicerin protects pancreatic acinar cells from caerulein-induced apoptosis, inflammation, and ferroptosis by activating the SIRT1/GPX4 signaling pathway. [Abstract]2024 Nov:492:117136. PMID: 39476876 -
Exp Cell Res
SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis. [Abstract]2019 Nov 1;384(1):111606. PMID: 31493386
Caerulein acetate purchased from MedChemExpress. Usage Cited in: Exp Cell Res. 2019 Nov 1;384(1):111606. [Abstract]
Decreased SPOP expression in cerulein-induced CP mice. Pancreatic SPOP, NF-κB/p65 and downstream proteins are determined through western blotting. Protein levels are normalized to the GAPDH loading control. Densitometry analysis is performed using the ImageJ software.
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Thromb Res
Leukadherin-1 mitigates disseminated intravascular coagulation in acute pancreatitis by suppressing necroptosis. [Abstract]2025 Aug:252:109363. PMID: 40494132 -
Arch Immunol Ther Exp (Warsz)
TAGLN2 Exacerbates Acute Pancreatitis-Induced Liver Injury by Increasing Hepatocyte Pyroptosis via Kupffer Cells-Mediated Inflammatory Response. [Abstract]2025 Jun 5;73(1). PMID: 40472315 -
Arch Immunol Ther Exp (Warsz)
Intraarterial Infusion of Lidocaine is Superior to the Subcutaneous Injection of Low Molecular Weight Heparin for Improving the Course of Cerulein-Induced Acute Pancreatitis in Rats. [Abstract]2025 Apr 16;73(1). PMID: 40237149 -
Pflugers Arch
miR-135a deficiency inhibits the AR42J cells damage in cerulein-induced acute pancreatitis through targeting FAM129A. [Abstract]2019 Dec;471(11-12):1519-1527. PMID: 31729558 -
Kaohsiung J Med Sci
ELAVL1-dependent SOAT2 exacerbated the pancreatitis-like cellular injury of AR42J cells induced by hyperstimulation with caerulein. [Abstract]2025 Jan;41(1):e12911. PMID: 39588852 -
J Gene Med
2024 Apr;26(4):e3683. PMID: 38571451 -
Dig Dis Sci
2022 Sep;67(9):4471-4483. PMID: 35094251 -
J Dig Dis
Porous SiO2 -coated ultrasmall selenium particles nanospheres attenuate cerulein-induce acute pancreatitis in mice by downregulating oxidative stress. [Abstract]2021 Jun;22(6):363-372. PMID: 33844454 -
Pancreas
MiR-204-5p Performs a Protective Effect on Cerulein-Induced Rat Pancreatic Acinar Cell AR42J Cell Damage by Targeting Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Gamma and Regulating PI3K/Hippo Pathways. [Abstract]2021 Feb 1;50(2):243-250. PMID: 33565802 -
Pancreas
Nuclear Factor-κB Increases Intracellular Calcium by Upregulation of Na+-Ca2+ Exchanger 1 in Cerulein-Induced Acute Pancreatitis. [Abstract]2020 Jan;49(1):111-119. PMID: 31856086 -
Exp Ther Med
2019 Aug;18(2):1246-1252. PMID: 31363368 -
Exp Anim
The KLF4-STAT5 axis promotes pancreatic fibrosis in mice with caerulein-induced chronic pancreatitis. [Abstract]2023 Aug 7;72(3):379-388. PMID: 36948613 -
Braz J Med Biol Res
Lapiferin protects against H1N1 virus-induced pulmonary inflammation by negatively regulating NF-kB signaling. [Abstract]2020;53(10):e9183. PMID: 32901688 -
Can J Physiol Pharmacol
2019 Jan;97(1):15-22. PMID: 30326193
Caerulein acetate purchased from MedChemExpress. Usage Cited in: Can J Physiol Pharmacol. 2019 Jan;97(1):15-22. [Abstract]
Expressions of Wnt/β-Catenin pathway-related genes in pancreatic and small intestinal tissues in each group (control, Caerulein, SKL2001+Caerulein, SKL2001+control). Relative mRNA expressions of Wnt1 (A, F), Wnt2 (B, G), β-catenin (C, H), c-Myc (D, I) and Axin-2 (E, J) in pancreatic and small intestinal tissues in each group detected by qRT-PCR.
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Am J Transl Res
Augmenter of liver regeneration (ALR) regulates acute pancreatitis via inhibiting HMGB1/TLR4/NF-κB signaling pathway. [Abstract]2018 Feb 15;10(2):402-410. PMID: 29511434
Caerulein acetate purchased from MedChemExpress. Usage Cited in: Am J Transl Res. 2018 Feb 15;10(2):402-410. [Abstract]
Cerulein exposure increases the protein expression of MD2, while ALR reduces the Cerulein-induced upregulation in MD2 protein expression.
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Heliyon
Paeoniflorin increases the anti-tumor efficacy of sorafenib in tumor-bearing mice with liver cancer via suppressing the NF-κb/PD-l1 axis. [Abstract]2024 Jan 13;10(2):e24461. PMID: 38312647 -
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Oxid Med Cell Longev
Dopamine D2 Receptor Signaling Attenuates Acinar Cell Necroptosis in Acute Pancreatitis through the Cathepsin B/TFAM/ROS Pathway. [Abstract]2022 Jul 26:2022:4499219. PMID: 35927992 -
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Environ Toxicol
2021 Dec;36(12):2392-2403. PMID: 34423886 -
Biomed Pharmacother
2020 Jul:127:110116. PMID: 32428833 -
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Oxid Med Cell Longev
DPP4 Inhibitor Attenuates Severe Acute Pancreatitis-Associated Intestinal Inflammation via Nrf2 Signaling. [Abstract]2019 Nov 15:2019:6181754. PMID: 31827684
Pureté et documentation
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Pureté:
99.98%
Assay:
99.98%
ee.:
99.98%
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